Complex patterns of direct and indirect association between the transcription Factor-7 like 2 gene, body mass index and type 2 diabetes diagnosis in adulthood in the Hispanic Community Health Study/Study of Latinos

ConclusionsHerein, we replicated the protective effect of rs7930146-T on body mass index at multiple time  points in the life course, and observed that these effects were not explained by past type 2 diabetes status in our structured modeling. The robust replication of the negative effects ofTCF7L2 on body mass index in multiple samples, including in our diverse Hispanic/Latino community-based sample, supports a growing body of literature on the complex biologic mechanism underlying the functional consequences ofTCF7L2 on obesity and type 2 diabetes across the life course.
Source: BMC Obesity - Category: Eating Disorders & Weight Management Source Type: research