Ethics and the Future of Vascularized Composite Allotransplantation

AbstractPurpose of ReviewThis paper seeks to identify and examine a number of ethical issues that persist 20  years after the field of vascularized composite allotransplantation was established. Reflection upon these issues will be essential if the field is to fulfill its promise.Recent FindingsA number of scholars, including the authors, have been involved in efforts to identify ethical issues in VCA. Meetings held in the US and in Europe have focused on ethical concerns related to procurement, risk-benefit, consent, and program standards, among others.SummaryImproving the burden and risk vs. benefit ratio, strengthening the consent process, employing a patient advocate, bringing greater clarity to donation policy, and improving data sharing are identified as major ethical concerns in vascularized composite allotransplantation.
Source: Current Transplantation Reports - Category: Transplant Surgery Source Type: research

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Hi everyone, As we know Heart Failure and Transplant fellowship is going for match this year. I just submitted my application, lets use this thread to connect people who are applying to it. Please share our interview invites and also I saw that some of the big programs like Mayo clinic, Univ of Michigan are not taking part in the ERAS. Does anyone know if they took already decided there candidate or do we need to apply to them separately? Does any one know any other programs who have... Advance Heart Failure and Transplant fellowship 2019-2020
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Cardiology Source Type: forums
Authors: Dutta SK, Verma S, Jain V, Surapaneni BK, Vinayek R, Phillips L, Nair PP Abstract The role of the microbiome in health and human disease has emerged at the forefront of medicine in the 21st century. Over the last 2 decades evidence has emerged to suggest that inflammation-derived oxidative damage and cytokine induced toxicity may play a significant role in the neuronal damage associated with Parkinson's disease (PD). Presence of pro-inflammatory cytokines and T cell infiltration has been observed in the brain parenchyma of patients with PD. Furthermore, evidence for inflammatory changes has been reported i...
Source: Journal of Neurogastroenterology and Motility - Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research
ConclusionsIn summary, our study demonstrated that age-related miR-219a-5p can attenuate hepatic I/R injury through inhibiting TP53BP2 and downstream TP53-dependent apoptosis of hepatic cells in mice.
Source: Digestive Diseases and Sciences - Category: Gastroenterology Source Type: research
Dr Alok Patel speaks with Dr Jessica Allegretti on what she learned from applying fecal microbiota transplantation as a treatment for obesity in otherwise healthy patients.Medscape Gastroenterology
Source: Medscape Gastroenterology Headlines - Category: Gastroenterology Tags: Gastroenterology Commentary Source Type: news
Publication date: Available online 22 July 2019Source: Pharmacological ResearchAuthor(s): Priyankar DeyAbstractThe dynamic and delicate interactions amongst intestinal microbiota, metabolome and metabolism dictates human of health and disease. In recent years, our understanding of gut microbial regulation of intestinal immunometabolic and redox homeostasis have evolved mainly out of studies related to in vivo studies associated with high-fat feeding induced metabolic diseases. Techniques utilizing fecal transplant and germ-free mice have been instrumental in reproducibly demonstrating how the gut microbiota affects disease...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
Condition:   Liver Transplantation Intervention:   Drug: Omega 3 fatty acid Sponsor:   Institute of Liver and Biliary Sciences, India Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   New Onset Diabetes After Transplant;   Diabetes Mellitus Intervention:   Other: group education Sponsor:   Dasman Diabetes Institute Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Temple University Hospital and Bethlehem-based St. Luke ’s University Health Network said Tuesday they have entered into an expanded affiliation that now includes lung transplants and advance lung disease care. Financial terms of the deal were not announced. Under the partnership, patients living in the Lehigh Valley will get “streamlined” access — close to home — to Temple’s experienced lung transplant team and pulmonology specialists. The alliance expands on the clinical affiliation…
Source: bizjournals.com Health Care:Pharmaceuticals headlines - Category: Pharmaceuticals Authors: Source Type: news
Although modifications of gut microbiota with antibiotics (Abx) influence mouse skin and cardiac allografts, its role in orthotopic liver transplantation (OLT) remains unknown. We aimed to determine whether and how recipient Abx pretreatment may affect hepatic ischemia-reperfusion injury (IRI) and OLT outcomes. Mice (C57BL/6) with or without Abx treatment (10 days) were transplanted with allogeneic (BALB/c) cold-stored (18 hours) livers, followed by liver and blood sampling (6 hours). We divided 264 human OLT recipients on the basis of duration of pre-OLT Abx treatment into control (Abx-free/Abx
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Organ transplantation is now a preferred treatment for end-stage organ failure. Among the challenges for ensuring excellent clinical outcomes for transplant recipients is good initial allograft function at the time of organ implantation. This is determined in part by the functional status of the donor and donor organ, functional status of the recipient, and conduct of the operative procedure. Despite optimization of these variables, organ transplantation is still often plagued by substantial initial dysfunction, variably referred to as slow or delayed graft function, or in the most extreme cases, primary graft nonfunction ...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
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