Mitochondrial aconitase is a key regulator of energy production for growth and protein expression in Chinese hamster ovary cells

ConclusionTransient silencing of mitochondrial aconitase inhibited cell growth, reduced ATP production, increased production of reactive oxygen species and reduced cell specific productivity of a recombinant CHO cell line by at least twofold.

Source: Metabolomics - October 1, 2018 Category: Biology Source Type: research