Air –blood barrier thickening and alterations of alveolar epithelial type 2 cells in mouse lungs with disrupted hepcidin/ferroportin regulatory system

In conclusion, disruption of systemic iron homeostasis affects the ultrast ructure of interalveolar septa which is characterized by membrane-bound iron storage in AE1 cells, thickening of the air–blood barrier and hyperplasia and hypotrophy of AE2 cells despite normal total intracellular surfactant pools. The functional relevance of these findings requires further analys is to better understand the impact of iron on intra-alveolar surfactant function.

Source: Histochemistry and Cell Biology - October 3, 2018 Category: Biomedical Science Source Type: research