Chronic Lung Allograft Dysfunction

AbstractPurpose of ReviewSynthesize recent developments in the understanding of chronic lung allograft dysfunction (CLAD) epidemiology, pathophysiology, outcomes, and treatments with a focus on the classification of CLAD into restrictive allograft syndrome (RAS) and from bronchiolitis obliterans syndrome (BOS).Recent FindingsChronic lung allograft dysfunction (CLAD) remains the leading cause of long-term morbidity and mortality in lung transplant recipients. Despite the lack of progress on improving outcomes, significant progress has been made in better characterizing the disease ’s clinical and pathologic diversity. Most significantly, the clinical diagnosis of restrictive allograft syndrome (RAS) has been recognized as pathophysiologically distinct from bronchiolitis obliterans syndrome (BOS). Azithromycin remains the only treatment proven effective for CLAD, and its use has a modest impact on survival.SummaryImportant steps towards better classification and understanding of the CLAD disease processes have been made; however, more research is needed to develop effective therapies for this devastating condition.
Source: Current Respiratory Care Reports - Category: Respiratory Medicine Source Type: research