Lyme disease: diagnosis and management.

Lyme disease: diagnosis and management. Pract Neurol. 2018 Oct 03;: Authors: Ross Russell AL, Dryden M, Pinto AA, Lovett J Abstract Lyme disease (borreliosis) is a tick-borne bacterial infection caused by the spirochaete Borrelia burgdoferi, transmitted by hard-backed Ixodes ticks. Actual numbers of cases are increasing and it appears that the distribution across the UK is widening; however, it occurs most frequently in area of woodland, with temperate climate. It typically presents in mid to late summer. Lyme disease is a multisystem disease. The nervous system is the second most commonly affected system after the skin. Other systemic manifestations, such as carditis, keratitis, uveitis and inflammatory arthritis, rarely occur in European Lyme disease. In 2018, the National Institute for Health and Care Excellence has updated its guidelines on the diagnosis and management of Lyme disease. Here, we highlight important aspects of this guidance and provide a more detailed review of the clinical spectrum of neuroborreliosis, illustrated by cases we have seen. PMID: 30282764 [PubMed - as supplied by publisher]
Source: Practical Neurology - Category: Neurology Authors: Tags: Pract Neurol Source Type: research

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Authors: Curtis JR, Brahe CH, Østergaard M, Hetland ML, Hambardzumyan K, Saevarsdottir S, Wang X, Flake DD, Sasso EH, Huizinga TW Abstract OBJECTIVE: To compare the multi-biomarker disease activity (MBDA) score with the DAS28-CRP and CRP for predicting risk of radiographic progression in patients with rheumatoid arthritis. METHODS: Published studies of the MBDA score and radiographic progression with ≥100 patients per cohort were evaluated. Rates of radiographic progression over 1 year were determined across the low/moderate/high categories for MBDA score (low/moderate/high: 44), DAS28-CRP (low/modera...
Source: Current Medical Research and Opinion - Category: Research Tags: Curr Med Res Opin Source Type: research
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Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
In conclusion, the formulation of QCT- NE gel is an efficient topical treatment strategy for rheumatoid arthritis.Graphical abstract
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
This study reports anti-arthritic potential of opuntioside-I opuntiol, and its gold and silver nanoparticles (NPs) against Complete Freund’s Adjuvant (CFA)-induced arthritic rats. The mechanistic studies were performed targeting TLRs (TLR-2 and TLR-4) and cytokines (IL-1β and TNF-α) expressions to validate their anti-inflammatory and immuno-modulatory response.The nano-formulations were successfully characterized employing Atomic Force Microscopy (AFM) and Dynamic Light Scattering (DLS) analysis. Opuntiol and opuntioside (OP and OPG: 10, 50 and 100 mg/kg) and opuntiol-coated silver and gold NPs (OP-...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
This study provides the first large-scale transcriptional dataset for the biosynthetic pathways of triterpene saponins and their phytohormonal responsiveness in the genus Anemone.
Source: Chinese Journal of Natural Medicines - Category: Complementary Medicine Source Type: research
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Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
is the most common tick-borne illness in the USA and Europe. Pathogens involved are Borrelia burgdorferi in the USA and B. afzelii and B. garinii in Europe. The characteristic rash of erythema migrans occurs in approximately 75% of patients. Neurological disease, including facial palsy, meningoencephalitis, aseptic meningitis and polyradiculopathy, occurs in 10 –15%. Cardiac disease, primarily manifest as heart block, is seen in 1–2%. Arthritis is seen as a late complication in about 30%.
Source: Medicine - Category: Internal Medicine Authors: Tags: Bacterial infections Source Type: research
Ticks and the diseases they carry have long been recognized as health concerns, especially in the warmer months when ticks (and humans) are more active. Ticks wait on grass tips or shrubs to latch onto new hosts when they brush by. Most of the hosts are animals, but a few tick species do bite and feed on humans. While doing so, they can transmit bacteria and viruses through their saliva. But here’s what’s changing: Tick species are being found in a wider geographic range. The number of case reports of tick-borne illnesses is increasing. Scientists continue to identify new pathogens (bacteria and viruses that c...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Health Infectious diseases Prevention Safety Travel health Source Type: blogs
Ticks and the diseases they carry have long been recognized as health concerns, especially in the warmer months when ticks (and humans) are more active. Ticks wait on grass tips or shrubs to latch onto new hosts when they brush by. Most of the hosts are animals, but a few tick species do bite and feed on humans. While doing so, they can transmit bacteria and viruses through their saliva. But here’s what’s changing: Tick species are being found in a wider geographic range. The number of case reports of tick-borne illnesses is increasing. Scientists continue to identify new pathogens (bacteria and viruses that c...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Health Infectious diseases Prevention Safety Travel health Source Type: blogs
CONCLUSION: PET/CT imaging with [(18)F]FDG is a reliable method to longitudinally monitor the development and progression of B. burgdorferi infection-induced inflammation in vivo in mouse joints. PMID: 28649922 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Rheumatology - Category: Rheumatology Authors: Tags: Scand J Rheumatol Source Type: research
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