Medicinal properties of Clerodendrum glaburum E may leaf extracts: phytochemical constituents, antioxidant, cytotoxicity, and carbohydrate-metabolizing enzyme inhibitory potentials
AbstractThe phytochemical constituents, antioxidant, and cytotoxicity as well as the inhibitory potentials ofClerodendrum glaburum on key carbohydrate metabolizing enzymes were investigated. The plant sample was extracted separately with hexane, EtOAc, MeOH, and water. The phytochemical analysis and antioxidant assays of the extracts were achieved using standard procedures; the antidiabetic capability of the extracts against the actions of α-amylase and α-glucosidase was examined while their cytotoxicity was tested against Vero cells. Highest quantity of phenol (65.97 mg gallic acid g−1), flavonoid (47.02 mg quercetin g−1), and flavanol (173.74 mg catechin g−1) were observed in MeOH extract. Also, MeOH extract had the most potent ability (p
Conclusion: In this study, frequent regular use of over-the-counter mouthwash was associated with increased risk of hypertension, independent of major risk factors for hypertension and several other potential confounders. PMID: 31709856 [PubMed - as supplied by publisher]
CONCLUSION: There was a good agreement for the size of the NVs in both methods. OCTA can be used as a simple and non-invasive method to visualize retinal neovascularizations. PMID: 31711250 [PubMed - in process]
Publication date: Available online 11 November 2019Source: Chemico-Biological InteractionsAuthor(s): Nehal M. Elsherbiny, Eman Said, Hoda Atef, Sawsan A. ZaitoneAbstractType 2 diabetes mellitus (T2DM) is a disease with a drastically growing worldwide prevalence. It is usually associated with numerous complications of which; diabetic nephropathy (DN); is a main complication of microvasculature and more seriously, a common cause of end-stage renal disease (ESRD). Unfortunately, both the lack of a definitive remedy alongside the economic and the social burden on DN patients enforces considerable impetus for developing alterna...
Authors: Shatta A, Bissada NF, Ricchetti P, Paes A, Demko C Abstract PURPOSE: To assess the pattern of bone loss in peri-implantitis in partially edentulous patients and relate patient and implant/site characteristics that may influence such patterns. MATERIALS AND METHODS: In this retrospective study, the records of partially edentulous patients with dental implants were stratified according to sex, age, smoking, and diabetes. Implants were stratified according to site, number of years in function, presence of adjacent implants, diameter, bone-grafted site, and implant platform. All these variables were obtain...
Authors: Ohara N, Kobayashi M, Ikeda Y, Hoshi T, Morita S, Kanefuji T, Yagi K, Suda T, Takada T, Hasegawa G, Sato Y, Hirano K, Kosugi SI Abstract A 70-year-old man with insulinoma-associated antigen-2 autoantibodies developed diabetes mellitus (DM) without ketoacidosis after starting nivolumab to treat advanced gastric cancer. He subsequently exhibited preserved insulin-secretion capacity for over one year. Immune-checkpoint inhibitors (ICIs) infrequently cause type 1 DM associated with the rapid loss of insulin secretion and ketoacidosis as an immune-related adverse event. ICIs may also cause non-insulin-dependent...
Conclusions: Key HIV-related parameters reflective of nonacute infection (increased duration of HIV and duration of antiretroviral therapy use) or relatively reduced immunologic function (lower CD4 count) were linked to reduced expression of brown and beige fat gene in the abdominal subcutaneous adipose depot. Clinical Trial Registration: NCT01098045.
DiabetesMine reviews Baqsimi, the new nasal rescue glucagon from Eli Lilly, the first-ever product of its kind without needles.
Contaminants in air, water, and food are linked directly or epidemiologically to neurologic diseases and neurodevelopmental disorders. Nanoparticle solids and endocrine disruptors are major factors.Medscape Medical News
ConclusionsIn this high-risk low-income cohort, contributions of risk factors to HF varied, particularly by race. To reduce the population burden of HF, interventions tailored for specific race and sex groups may be warranted.Graphical abstract