Evaluation of the toxicopathological lesions of Calotropis procera using a chick embryonic model

AbstractToxicopathological effects of herbs have always been a major concern. There is scant information available about the toxicopathological effects ofCalotropis procera (C. procera) in the fetus. Since the chick embryo is a suitable preclinical model to evaluate the toxicopathological effects of chemicals, the objective of this study is to evaluate the lesions of various dosages ofC. procera using a chick embryonic model. Fertile chicken eggs were divided into three equal treatment groups; phosphate buffered saline-injected group andC. procera-injected groups whose individuals were treated withC. procera extract at dosages of 50 or 100  mg/kg egg-weight. Embryos were re-incubated post-treatment and allowed to develop until day 18, after which they were examined for macroscopic and microscopic lesions. Although the embryos which were treated with 50 mg/kg egg-weight ofC. procera extract macroscopically were normal as well as the controls, those treated with 100  mg/kg egg-weight were stunted and under developed. Microscopic evaluations showed that in embryos treated with 100 mg/kg egg-weight ofC. procera, the brain was congested, and severe dilation of central veins and sinusoids as well as hepatocellular degeneration was occurred in liver. Moreover, the kidney and lung were under-developed, but the structure of the heart was normal. Based on our findings,C. procera at dosage of 100  mg/kg is toxic to the chick embryo or/maybe to human fetus during...
Source: Comparative Clinical Pathology - Category: Pathology Source Type: research

Related Links:

ConclusionThese results indicate that A. farnesiana pods contain nematocidal compounds and might be promising natural anthelmintic agents against H. contortus. This leguminous plant could be used as a nutraceutical food source for the control of gastrointestinal nematodes in small ruminants.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
ConclusionThe Wallace rule of nines is a quick and acceptable method for estimating the total burn surface area percentage in men of all BMI ranges. However, for women, a more accurate method of burn area estimation is required as proposed by our BMI adjusted charts.
Source: Burns - Category: Dermatology Source Type: research
ConclusionsThe sagittal skeletal relationship showed no influence on the alveolar thickness or height, even if dental compensation was present. Hyperdivergent individuals showed smaller alveolar thicknesses and heights than hypodivergent individuals.RésuméObjectifL’os alvéolaire entourant les incisives mandibulaires donne les limites dans l’inclinaison buccolinguale pouvant être atteintes avec un traitement. L’objectif de cette étude était d’évaluer l’épaisseur et la hauteur alvéolaires antérieures mandibulaires chez des suje...
Source: International Orthodontics - Category: Dentistry Source Type: research
Transthyretin amyloid deposition is present in 17% of autopsies of patients with heart failure and a preserved ejection fraction (HFpEF). 99mTechnetium-pyrophosphate scintigraphy (99mTc-PYP) is sensitive and specific to diagnose cardiac transthyretin amyloid deposition (ATTR). The prevalence of ATTR by 99mTc-PYP was evaluated along with echocardiographic parameters in patients with HFpEF. One-hundred consecutive patients with HFpEF, who had 99mTc-PYP, were retrospectively evaluated. Echocardiographic variables were analyzed to compare patients with positive versus negative ATTR infiltration. Myocardial ATTR was present in ...
Source: Critical Pathways in Cardiology - Category: Cardiology Tags: Original Articles Source Type: research
We report on the advance of freeze-dried mucoadhesive orodispersible tablets (ODTs) loaded with prilocaine (PRC) and lidocaine (LDC) hydrochlorides, aiming to promote noninvasive buccal anesthesia. The influences of combining biocompatible polymers (pullulan and HPMC K100 LV) and a blend of surfactants (oleic acid, polysorbate 80 and propylene glycol) acting as chemical enhancers on the permeation of such drugs through the esophageal porcine epithelium and in vitro mucoadhesion were investigated. The ODTs were also characterized in terms of average weight, thickness, pH, drug content, in vitro release, thermal behavior and...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
Publication date: December 2019Source: Materials Science and Engineering: B, Volume 251Author(s): Nasser Arsalani, Yasaman Panahian, Ramin NasiriAbstractMagnetic bronze F-TiO2/carbon nanostructures nanocomposites were facilely synthesized by using TTIP (titanium tetraisopropoxide) and carbon nanostructures (Multi-walled carbon nanotube (MWCNT) or Fullerene (C60)) as precursors via the hydrothermal process. The structure of the magnetic nanocomposites have been characterized by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction analysis (XRD), UV–Vis diffuse reflectance spectroscopy, field emission scan...
Source: Materials Science and Engineering: B - Category: Materials Science Source Type: research
In this study, the microstructure characterization, mechanical properties and degradation behaviors of the Mg-xZn-0.1Mn-0.2Ca alloys with various Zn contents were analyzed via the polarization test, electrochemical impedance spectroscopy and the static immersion measurements. Meantime, the surface film layer features and the phase constitutions of the degradation production were characterized via the confocal laser scanning microscopy (3D/CLSM) and scanning electron microscopy. The results indicated that the more secondary phases appeared and the grain sizes were remarkably refined with the further addition of Zn, such as ...
Source: Materials Chemistry and Physics - Category: Materials Science Source Type: research
This study provides a new insight for the design of a low cost, eco-friendly and visible light driven photocatalyst, and innovative conversion of Durio zibethinus shell ash into a highly valuable nanocomposite for the effective purification of water contaminants.
Source: Journal of Materials Research and Technology - Category: Materials Science Source Type: research
Publication date: Available online 15 November 2019Source: Journal of Materials Research and TechnologyAuthor(s): Yan Zhang, YanKun Chen, JianPing Zhou, DaQian Sun, HongMei LiAbstractLaser welding-brazing of TC4 Titanium (Ti) alloy to 304 stainless steel (SS) has been applied using 38Zn-61Cu alloy as filler metal. Microstructures of the joints were studied using scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS) and X-ray diffraction (XRD). Mechanical properties of the joints were evaluated by performing tensile tests. The temperature field and stress field distributed in laser welding based on SS-Ti ...
Source: Journal of Materials Research and Technology - Category: Materials Science Source Type: research
Publication date: Available online 14 November 2019Source: NeuroImageAuthor(s): Xirui Hou, Peiying Liu, Yang Li, Dengrong Jiang, Jill B. De Vis, Zixuan Lin, Sandeepa Sur, Zachary Baker, Deng Mao, Harshan Ravi, Karen Rodrigue, Marilyn Albert, Denise C. Park, Hanzhang LuAbstractCerebrovascular reactivity (CVR) mapping using CO2-inhalation can provide important insight into vascular health. At present, blood-oxygenation-level-dependent (BOLD) MRI acquisition is the most commonly used CVR method due to its high sensitivity, high spatial resolution, and relatively straightforward processing. However, large variations in CVR acr...
Source: NeuroImage - Category: Neuroscience Source Type: research
More News: Brain | Cardiology | Chemistry | Heart | Herbs | Liver | Neurology | Pathology | PET Scan | Study | Toxicology | Urology & Nephrology