The critical interaction between valproate sodium and warfarin: case report and review.

CONCLUSION: By reviewing the literature and discussing the critical interaction between valproate sodium and warfarin, we conclude that intravenous VPA and the co-administrated warfarin may develop critical but underrecognized complications due to effects on the function of hepatic enzymes and displacement of protein binding sites. PMID: 30285858 [PubMed - in process]
Source: BMC Pharmacology and Toxicology - Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research

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Conclusion: We report a 33.9% positive yield, with 65.8% of patients undergoing further workup as a result of CE and 12.7% requiring therapeutic intervention. We conclude that CE plays an important role in the investigation of IDA and occult gastrointestinal bleeding and has important implications on further management.
Source: Journal of Clinical Gastroenterology - Category: Gastroenterology Tags: ALIMENTARY TRACT: Original Articles Source Type: research
The objective of this study was to develop an in-situ gel containing lorazepam (LZM) loaded nanostructured lipid carriers (NLCs) for direct nose-to-brain delivery in order to increase drug therapeutic efficacy in the treatment of epilepsy. Accordingly, LZM loaded NLCs were formulated using emulsification solvent diffusion and evaporation method; then the effects of the formulation variables on different physicochemical characteristics of NLCs were investigated. Thermosensitive in-situ gels containing LZM-NLCs were prepared using a combination of chitosan and β-glycerol phosphate (β-GP). The anticonvulsant efficac...
Source: IET Nanobiotechnology - Category: Nanotechnology Source Type: research
Publication date: Available online 9 April 2020Source: Journal of Physics and Chemistry of SolidsAuthor(s): Levent Semiz
Source: Journal of Physics and Chemistry of Solids - Category: Physics Source Type: research
Publication date: Available online 8 April 2020Source: Journal of Molecular LiquidsAuthor(s): Mehdi Bagheri, Farhoush Kiani, Fardad Koohyar, Nguyen Truong Khang, Fatemeh Zabihi
Source: Journal of Molecular Liquids - Category: Molecular Biology Source Type: research
Phys. Chem. Chem. Phys., 2020, Advance Article DOI: 10.1039/D0CP00172D, PaperAmbar Deshkar, Ozgur Gulbiten, Randall E. Youngman, John C. Mauro, Ashutosh Goel Addition of B2O3 in aluminosilicate glasses leads to structural changes that cause increase in liquidus viscosity and thereby suppresses crystallization. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Phys. Chem. Chem. Phys. latest articles - Category: Chemistry Authors: Source Type: research
J. Mater. Chem. A, 2020, Accepted Manuscript DOI: 10.1039/D0TA01281E, PaperLiangyu Wang, Chao Ma, xiao Wei, Baobao Chang, Kai-Xue Wang, Jie-Sheng Chen Organic electrode materials with high specific capacity and structural variety are promising in boosting the sodium-ion insertion/extraction kinetics for sodium-ion batteries. Sodium 5,5'-carbonylbis(isobenzofuran-1,3-dione) (SCID), a conjugated compound that bridges a... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - J. Mater. Chem. latest articles - Category: Chemistry Authors: Source Type: research
AbstractThere is no strong evidence on pharmacogenetics role on the quality of INR control after the initiation phase and on the maintenance of stable INR on the long term as measured by the time in therapeutic range (TTR). The benefit of a score such as SAMe-TT2R2 is that it can preemptively guide clinicians on whether to start the patient on warfarin or direct oral anticoagulant. To determine the association between genetic variants inCYP2C9, VKORC1, andCYP4F2 and TTR. To validate SAMe-TT2R2 score predictive ability on the quality of anticoagulation in Qatari patients. This is an observational nested case –control ...
Source: Journal of Thrombosis and Thrombolysis - Category: Hematology Source Type: research
ConclusionsThe metabolic changes in FTLD are promising diagnostic and prognostic biomarkers. Further work is required to replicate these findings, examine longitudinal change, and test their utility in differentiating between FTLD syndromes that are pathologically distinct but phenotypically similar.
Source: Journal of Neurology - Category: Neurology Source Type: research
Charlotte Figi, a child with a catastrophic type of epilepsy who went on to inspire a CBD movement, has passed away at age 13. CNN's Dr. Sanjay Gupta reflects on her life.
Source: - Health - Category: Consumer Health News Source Type: news
Conclusions: This is an institution-based, detailed, and descriptive epidemiological study of patients with primary CNS tumors in Saudi Arabia. In contrast to other regional and international studies, the medulloblastomas in our institution are more frequent than pilocytic astrocytomas. Limitations to our study included the referral bias and histology-based methodology. PMID: 32256589 [PubMed]
Source: Journal of Cancer Epidemiology - Category: Epidemiology Tags: J Cancer Epidemiol Source Type: research
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