What Is the Best Systemic Therapy for Left-sided RAS Wild-type Metastatic Colorectal Cancer?

AbstractPurpose of ReviewThere is a significant difference in embryological origin, gene expression, gene mutation profile, and microbiome between the right-sided and left-sided colon. It has been shown that the sidedness of primary colorectal cancer is a significant prognostic factor and predictive to the clinical benefit of anti-epidermal growth factor receptor (EGFR) antibody-containing chemotherapy in patients with metastatic CRC. Herein, current clinical recommendations for the treatment of patients with left-sidedRAS wild-type mCRC are reviewed.Recent FindingsRetrospective analyses of prior randomized trials (CRYSTAL, PRIME, FIRE-3, CALGB 80405, and PEAK trials) showed that primary tumor sidedness is predictive to anti-EGFR antibody therapy in the first-line treatment of patients withRAS wild-type mCRC, and patients with left-sidedRAS wild-type mCRC had a significantly better survival benefit with anti-EGFR antibody plus chemotherapy when compared with anti-VEGF treatment plus chemotherapy.SummaryThe primary tumor sidedness is a significant prognostic factor and predictive to anti-EGFR antibody-containing chemotherapy in patients with metastatic CRC. Based on the currently available data, chemotherapy plus anti-EGFR antibody is recommended for the first-line treatment of patients with left-sidedRAS wild-type mCRC. Chemotherapy plus bevacizumab or anti-EGFR antibody is recommended for the second-line therapy ofRAS wild-type mCRC regardless of sidedness. However, these re...
Source: Current Colorectal Cancer Reports - Category: Cancer & Oncology Source Type: research

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In conclusion, MAG prevents the appearance of sensitive axonal neuropathy and neuromuscular disorders induced by oxaliplatin without affecting its antitumor activity. PMID: 31741707 [PubMed]
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Some of the most common symptoms experienced by cancer patients are memory problems, difficulties with multitasking, and reduced attention and concentration. Historically, cancer patients with these symptoms were often diagnosed with depression. Research over the past decade has revealed that many cancer patients experience such symptoms as a consequence of specific damage to the brain caused by either their tumor or their treatment. While radiation to the brain has long been linked to causing cognitive difficulties, the effects of chemotherapy on brain structure and function have only recently been discovered. We now know...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Brain and cognitive health Cancer Memory Radiation Source Type: blogs
BOSTON (CBS) – Throughout high school and into college, Alicia Staley of Middleton dreamed of being an astronaut. A quick look around her home office and you will see a small model space shuttle and NASA stickers all over her laptop. “Unfortunately, I had to give up my dream of being an astronaut after being so sick.” Alicia was diagnosed with lymphoma during her sophomore year at Syracuse University. She managed to stay in school while enduring months of grueling chemotherapy and radiation. “It was tough. I felt extraordinarily alone,” she recalled. She beat the lymphoma, only to be diagnosed...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Boston News Featured Health Boston Influencers Breast Cancer Source Type: news
ConclusionAlthough classically, majority of studies have shown oncogenic roles of nucleoporins as genetic fusion partners in several types of leukemia, emerging evidence suggests that nucleoporins also modulate many cellular signaling pathways that are associated with several major non-hematological malignancies, such as carcinomas of skin, breast, lung, prostate and colon. Hence, nucleoporins are emerging as novel therapeutic targets in human tumors.
Source: Journal of Cancer Research and Clinical Oncology - Category: Cancer & Oncology Source Type: research
CONCLUSION: Surgical oncologists consider the patient's condition and postoperative course rather than high-risk factors to determine use of AC. Regardless of AC use, both the extent of surgery and the patient's subsequent status affected the survival rate in the high-risk group. None of the factors identified influenced survival rate in the low-risk group. PMID: 31726001 [PubMed]
Source: Annals of Coloproctology - Category: Gastroenterology Tags: Ann Coloproctol Source Type: research
CONCLUSIONS: The Naples prognostic score may be a useful prognostic marker in patients with metastatic colorectal cancer receiving systemic chemotherapy. See Video Abstract at http://links.lww.com/DCR/B72. LA PUNTUACIÓN PRONÓSTICA DE NÁPOLES ES UN MARCADOR PRONÓSTICO ÚTIL EN PACIENTES CON CÁNCER COLORRECTAL METASTÁSICO ANTECEDENTES: La inflamación sistémica puede influir en la respuesta a la quimioterapia sistémica o el pronóstico en pacientes con varios tipos de cáncer. La puntuación pronóstica de Nápoles, basada...
Source: Diseases of the Colon and Rectum - Category: Gastroenterology Tags: Original Contributions: Colorectal Cancer Source Type: research
Publication date: Available online 12 November 2019Source: Journal of Functional FoodsAuthor(s): Mónica Lara-Márquez, Marisol Báez-Magaña, Cristina Raymundo-Ramos, Paul A. Spagnuolo, Lourdes Macías-Rodríguez, Rafael Salgado-Garciglia, Alejandra Ochoa-Zarzosa, Joel E. López-MezaAbstractColorectal cancer (CRC) is the third most common type of cancer worldwide. Chemotherapy used in CRC patients has severe side effects. As an alternative, the search to identify natural compounds increases the opportunity to select therapeutics. In this work, the cytotoxic effect of a lipid extra...
Source: Journal of Functional Foods - Category: Nutrition Source Type: research
Conditions:   Patient Empowerment;   Patient Activation;   Self Care;   Cancer of Colon;   Cancer of Rectum Intervention:   Behavioral: Educational nursing intervention on nutrition intake related chemotherapy induced side-effects' self-care among the patients with colorectal cancer Sponsors:   University of Turku;   Helsinki University Central Hospital Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
ConclusionsExpectedly, adjuvant radiation use was relatively low but was associated with improved OS in patients with both pT4 and positive margins.
Source: Annals of Surgical Oncology - Category: Cancer & Oncology Source Type: research
Collectively, successful delivery of miR and chemotherapy by pH ‐responsive targeting nanoparticles modulates β‐catenin/multiple drug resistance/apoptosis/metastasis pathways and induces cancer cell death, mainly via apoptosis. These pH‐sensitive targeting nanoparticles carrying chemotherapy and gene therapeutics remarkably enhance anticancer efficacy in tumor‐bearing mice. Thus, these nanoparticles may provide a potential regimen for effective treatment of colorectal cancer. AbstractIrinotecan is one of the main chemotherapeutic agents for colorectal cancer (CRC). MicroRNA ‐200 (miR‐200) has been reported...
Source: Small - Category: Nanotechnology Authors: Tags: Full Paper Source Type: research
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