IJERPH, Vol. 15, Pages 2156: Ferroportin-Hepcidin Axis in Prepubertal Obese Children with Sufficient Daily Iron Intake

IJERPH, Vol. 15, Pages 2156: Ferroportin-Hepcidin Axis in Prepubertal Obese Children with Sufficient Daily Iron Intake International Journal of Environmental Research and Public Health doi: 10.3390/ijerph15102156 Authors: Joanna Gajewska Jadwiga Ambroszkiewicz Witold Klemarczyk Ewa Głąb-Jabłońska Halina Weker Magdalena Chełchowska Iron metabolism may be disrupted in obesity, therefore, the present study assessed the iron status, especially ferroportin and hepcidin concentrations, as well as associations between the ferroportin-hepcidin axis and other iron markers in prepubertal obese children. The following were determined: serum ferroportin, hepcidin, ferritin, soluble transferrin receptor (sTfR), iron concentrations and values of hematological parameters as well as the daily dietary intake in 40 obese and 40 normal-weight children. The ferroportin/hepcidin and ferritin/hepcidin ratios were almost two-fold lower in obese children (p = 0.001; p = 0.026, respectively). Similar iron concentrations (13.2 vs. 15.2 µmol/L, p = 0.324), the sTfR/ferritin index (0.033 vs. 0.041, p = 0.384) and values of hematological parameters were found in obese and control groups, respectively. Iron daily intake in the obese children examined was consistent with recommendations. In this group, the ferroportin/hepcidin ratio positively correlated with energy intake (p = 0.012), dietary iron (p = 0.003) and vitamin B12 (p = 0.024). In the multivariate regression ...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research