The m6A‑methylase complex and mRNA export

Publication date: Available online 2 October 2018Source: Biochimica et Biophysica Acta (BBA) - Gene Regulatory MechanismsAuthor(s): Simon Lesbirel, Stuart A. WilsonAbstractDuring synthesis, mRNA undergoes a number of modifications such as capping, splicing and polyadenylation. These processes are coupled with the orderly deposition of the TREX complex on the mRNA and subsequent recruitment of the NXF1-P15 heterodimer which stimulates the nuclear export of mature mRNAs. mRNAs also undergo a number of internal modifications, the most common of which is the N6‑methyladenosine (m6A) modification. In this review we discuss the recent evidence of coupling between the m6A modification, RNA processing and export.

Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - October 5, 2018 Category: Genetics & Stem Cells Source Type: research