This Month in The Journal

Clinicians have long appreciated that excess albumin in urine (albuminuria) correlates with later development of cardiovascular and metabolic disease. What has been less clear, however, is the nature of this association, e.g., do the pathways leading to albuminuria cause cardiometabolic dysfunction? In this issue, Haas et  al. use data from the UK Biobank to address this question with greater precision than previously possible. After constructing and validating an albuminuria polygenic risk score from a large genome-wide association study, the authors investigated whether genetically elevated albuminuria is associat ed with an increased risk of cardiometabolic disease.
Source: The American Journal of Human Genetics - Category: Genetics & Stem Cells Authors: Tags: Editors' Corner Source Type: research