The role of genetic polymorphisms in the thymidylate synthase (TYMS) gene in methotrexate-induced oral mucositis in children with acute lymphoblastic leukemia
Conclusion
The TYMS 6-bp deletion and 2R3R polymorphism were not associated with MTX-induced oral mucositis. Validation studies in prospective cohorts are necessary to assess the possible role of the low-expression TYMS genotypes in relation to MTX-induced oral mucositis.
Source: Pharmacogenetics and Genomics - Category: Genetics & Stem Cells Tags: Original Article Source Type: research
More News: Acute Leukemia | Acute Lymphoblastic Leukemia | Cancer | Cancer & Oncology | Child Development | Children | Genetics | Leukemia | Methotrexate | Netherlands Health | Oral Cancer | Pediatrics | Statistics | Study | Toxicology