Is Early Complement Activation in Renal Transplantation Associated with Later Graft Outcome?

Conclusion: Complement deposition strongly correlated with histopathological changes observed in renal transplants. All 3 complement pathways were operational in biopsies with DGF, TCMR and ABMR albeit with differential abundance and localization. Since complement deposition in zero-biopsies correlated with graft function and morphological changes, early specific complement inhibition in renal transplantation may be a new therapeutic option to prevent graft loss.Kidney Blood Press Res 2018;43:1488 –1504
Source: Kidney and Blood Pressure Research - Category: Urology & Nephrology Source Type: research