Renal transplant recipients receiving loop diuretic therapy have increased urinary tract infection rate and altered medullary macrophage polarization marker expression

Loop diuretics deplete the renal cortico-medullary salt gradient that has recently been established as a major modulator of immune responses. Renal transplant recipients suffer from a markedly increased rate of urinary tract infections (UTIs). Whether diuretic therapy affects renal macrophage polarization in the human kidney graft and the incidence of UTI have not been reported. In a cohort of 112 adult renal allograft recipients, loop diuretic therapy significantly correlated with the rate of UTI during five years after transplantation in uni- and multivariable regression analysis.

Source: Kidney International - September 28, 2018 Category: Urology & Nephrology Authors: Janis Casper, Jessica Schmitz, Jan Hinrich Br äsen, Abedalrazag Khalifa, Bernhard M.W. Schmidt, Gunilla Einecke, Hermann Haller, Sibylle von Vietinghoff Tags: Clinical Investigation Source Type: research