Donor APOL1 high-risk genotypes are associated with increased risk and inferior prognosis of de novo collapsing glomerulopathy in renal allografts

Collapsing focal segmental glomerulosclerosis (cFSGS) in the native kidney is associated with heavy proteinuria and accelerated renal failure. However, cFSGS in the renal allograft is less well characterized. Here we report clinico-pathologic features and APOL1 donor risk genotypes in 38 patients with de novo post-kidney transplant cFSGS. Recipients were 34% female and 26% African American. Concurrent viral infections and acute vaso-occlusion (including thrombotic microangiopathy, cortical necrosis, atheroembolization, and cardiac arrest with contralateral graft thrombosis) were present in 13% and 29% of recipients, respectively.

Source: Kidney International - October 3, 2018 Category: Urology & Nephrology Authors: Dominick Santoriello, Syed A. Husain, Sacha A. De Serres, Andrew S. Bomback, Russell J. Crew, Elena-Rodica Vasilescu, Geo Serban, Eric S. Campenot, Krzysztof Kiryluk, Sumit Mohan, Gregory A. Hawkins, Pamela J. Hicks, David J. Cohen, Jai Radhakrishnan, Mic Tags: Clinical Investigation Source Type: research