Chronic illnesses: UN stands up to stop 41 million avoidable deaths per year
“Heart disease, stroke, cancer, diabetes, chronic Lyme disease, depression” – just some of the illnesses outlined by World Health Organization (WHO) chief Dr. Tedros Ghebreyesus, who drove home the danger by asking delegates to stand up, when they heard the name of an illness that had killed someone they loved: One by one, every single person in the room, got to their feet.
Conclusions: These results suggest that JAK/STAT3 and NF-κB signals play important roles in ATC-CSCs. Targeting these signaling pathways may be a promising approach to treat ATC. PMID: 30784360 [PubMed - as supplied by publisher]
More research suggests an association between high consumption of diet drinks and increased stroke, as well as a strong link between higher intake and small vessel occlusions.Medscape Medical News
The deal comes four months after Immune Design Corp. halted its lead cancer vaccine trial and restructured its drug development plans.
Geoffrey Turner, 66, of Latham, New York, passed away on February 13 after a three-month battle with lung cancer. His self-deprecating obituary appeared in the Albany Times-Union on Saturday.
In a study of more than 1100 participants, perioperative covert stroke occurred in 1 in every 14 patients — and was associated with increased risk for cognitive decline within 1 year postsurgery.Medscape Medical News
More than 6 million Americans live with disabilities following a stroke. Even mild strokes can leave survivors with arm and leg weakness, poor muscle control and memory lapses that worsen with age. Now UCLA neuroscientists have found that patients born without a gene called CCR5 recover better from mild stroke than patients with the gene. The team partnered with Israeli researchers to study the missing gene ’s effect on brain function.Published Feb. 21 in the journal Cell, the findings could lead to the first pill to reverse the physical and mental aftermath of mild stroke.“This is the first time tha...
Authors: Swannell C PMID: 30779149 [PubMed - in process]
Authors: De Luca L, Laurenzana I, Trino S, Lamorte D, Caivano A, Musto P Abstract INTRODUCTION: Multiple myeloma (MM) is characterized by a clonal proliferation of neoplastic plasma cells (PCs) in bone marrow (BM) and the interplay between MM PCs and the BM microenvironment, which plays a relevant role in its pathogenesis. In this important cross-talk, extracellular vesicles (EVs) are active. EVs, including small and medium/large EVs, are lipid bi-layer particles released in circulation by normal and neoplastic cells. A selected cargo of lipids, proteins, and nucleic acids is loaded into EVs, and delivered locally ...
Investigational agent sacituzumab govitecan showed activity in patients with metastatic urothelial cancer, including some previously treated with immune checkpoint inhibitors.Medscape Medical News
ABSTRACT Objectives: To compare warfarin and dabigatran for thromboembolic event prevention in patients with nonvalvular atrial fibrillation or atrial flutter. Methods: This was a retrospective cohort of participants with nonvalvular atrial fibrillation or atrial flutter using either warfarin or dabigatran in a reference center in Brazil. Results: There were 112 patients (mean age 65.5 years), with 55.3% using warfarin. The median duration of follow-up was 1.9 years for warfarin and 1.6 years for dabigatran (p = 0.167). Warfarin patients had a higher median of medical appointments per year (8.3 [6.8-10.4] vs 3.1 [2.3-4.2], p