Gastroesophageal reflux and Barrett ’s esophagus: a pathway to esophageal adenocarcinoma

AbstractThe incidence of esophageal adenocarcinoma (EAC) has increased significantly in Western countries. The rising prevalence of gastroesophageal reflux disease (GERD) and obesity has played a major role in the increasing numbers of EAC. Approximately 10 –15% of patients with GERD will develop Barrett’s esophagus (BE). This metaplastic transformation is due to the chronic injury produced by repeated reflux episodes and involves genetic mutations that can lead to a malignant transformation. Ultimately, the development of EAC is characterized by t he sequence BE metaplasia–dysplasia–invasive carcinoma.
Source: Updates in Surgery - Category: Surgery Source Type: research