New Drug Approved for Antibiotic-Resistant Lung Disease

Title: New Drug Approved for Antibiotic-Resistant Lung DiseaseCategory: Health NewsCreated: 10/1/2018 12:00:00 AMLast Editorial Review: 10/2/2018 12:00:00 AM
Source: MedicineNet Lungs General - Category: Respiratory Medicine Source Type: news

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As drug-resistant bacteria become prevalent, healthcare providers need strategies for keeping patients safe, as 2 million people in the United States are infected and 23,000 people die each year.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Nursing News Source Type: news
ConclusionOne third of healthy Thai neonates harboured antibiotic-resistantE. coli in meconium. The proportion of resistantE. coli increased during the first year of life almost reaching the value in adults. We hypothesize that enhancement of infection control measures and cautious use of antibiotics may help to control further increase of resistance.
Source: Antimicrobial Resistance and Infection Control - Category: Infectious Diseases Source Type: research
In this study, we examined the drug-resistance phenotypes and genotypes of 9 S. aureus strains. One strain was obtained from the China Center for Type Culture Collection (CCTCC), and the remaining eight strains were isolated from food. Two common methods (the Kirby-Bauer disk diffusion and broth microdilution methods) were used to detect bacterial drug resistance. Then, we analysed the relationship between the bacterial drug resistance phenotypes and genotypes. We found that some S. aureus strains isolated from food were drug-resistant or even multi-drug resistant and that there was not a perfect match between resistance p...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
Publication date: 18–24 May 2019Source: The Lancet, Volume 393, Issue 10185Author(s): Ziad A Memish, Robert Steffen, Paul White, Osman Dar, Esam I Azhar, Avinash Sharma, Alimuddin ZumlaSummaryMass gathering events are associated with major public health challenges. The 2014 Lancet Series on the new discipline of mass gatherings medicine was launched at the World Health Assembly of Ministers of Health in Geneva in May, 2014. The Series covered the planning and surveillance systems used to monitor public health risks, public health threats, and experiences of health-care providers from mass gathering events in 2012 and...
Source: The Lancet - Category: General Medicine Source Type: research
This study characterized 30 MRSA isolates from intensive care unit (ICU) environment and equipment surfaces and healthy children. The SCCmec types I, IVa and V were detected in HA-MRSA isolates while CA-MRSA showed the SCCmec type IVa and V. Most isolates were classified as agr group II. All isolates presented the sei gene, and only HA-MRSA were positive for etb e tst genes. Three genotypes were related to Pediatric (ST5/SCCmecIV) and Berlin (ST45/SCCmecIV) clones. The present study showed molecular similarity between CA- and HA-MRSA isolates in hospital and community settings in a Brazilian region.
Source: The Brazilian Journal of Infectious Diseases - Category: Infectious Diseases Source Type: research
This study aimed to investigate the prevalence of ermA, ermB, ermC, and msrA in MRSA strains isolated from burn patients in Ahvaz, southwest of Iran. A total of 76 isolates of S. aureus were collected from January to May 2017 from Taleghani Burn Hospital in Ahvaz. Among 76 S. aureus strains collected, 60 (78.9%) isolates were MRSA. The antimicrobial susceptibility testing for MRSA showed extreme high resistance rate to clarithromycin (100%) and azithromycin (100%), followed by erythromycin (98.3%). The PCR assay revealed that the frequency rates of msrA, ermA, and ermC genes were 23 (38.3%), 28 (46.7%), and 22 (36.7%), res...
Source: Acta Microbiologica et Immunologica Hungarica - Category: Microbiology Authors: Tags: Acta Microbiol Immunol Hung Source Type: research
Abstract Methicillin-resistant Staphylococcus aureus is a 'superbug' that is responsible for extensive death and morbidity. Chronic S. aureus infections are associated with the presence of intracellular bacteria and the host cytosol is an aerobic low-redox-potential (Eh) environment. How S. aureus adapts to aerobic low-Eh environments is understudied. A low external Eh, imposed by the non-metabolizable reductant dithiothreitol, resulted in transcriptional reprogramming mediated by the redox-responsive transcription factors AgrA, Rex and SrrBA, resulting in a shift towards fermentative metabolism. Accordingly, in t...
Source: Microbiology - Category: Microbiology Authors: Tags: Microbiology Source Type: research
This study aims at designing an efficient and benign antimicrobial silver-based ternary composite composed of photocatalysis zinc oxide (ZnO) and reduced graphene oxide (rGO) as a carrier, in which the reactive oxygen species (ROS) excited from ZnO and Ag+ ions released from the Ag NPs cooperate to realize an effective antibacterial activity against E. coli and S. aureus. The constant effective bacterial performance of the ternary photocatalyst with minimum Ag content can be attributed to the increase in the available quantity of ROS, which results from the enhanced separation efficiency of the photogenerated carriers. The...
Source: Chinese Journal of Catalysis - Category: Chemistry Source Type: research
Analyst, 2019, Accepted Manuscript DOI: 10.1039/C9AN00671K, PaperImaly Nanayakkara, Ian Matthew White As molecular diagnostics move away from polymerase chain reaction (PCR) in order to target point-of-care testing applications, loop-mediated isothermal amplification (LAMP) is gaining popularity due its rapid, sensitive and specific... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Analyst latest articles - Category: Chemistry Authors: Source Type: research
Publication date: Available online 15 May 2019Source: Enzyme and Microbial TechnologyAuthor(s): Jaewoo Bai, Eunhye Yang, Pahn-shick Chang, Sangryeol RyuABSTRACTThe overuse and misuse of antibiotics in treating bacterial infections cause the rapid emergence of drug-resistant bacteria, suggesting that the development of alternative strategies to control antibiotic-resistant bacteria is urgently needed. Endolysins are bacteriophage-encoded enzymes that can degrade peptidoglycan in bacterial cell walls, and they have great potential as alternative antimicrobial agents. However, exogenous application of recombinant endolysin is...
Source: Enzyme and Microbial Technology - Category: Biotechnology Source Type: research
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