Mechanism for pH-dependence of flucytosine against Aspergillus revealed

Mechanism for pH-dependence of flucytosine against Aspergillus revealedTue, 10/02/2018 - 13:50News blog
Source: The Aspergillus Website - updates - Category: Respiratory Medicine Authors: Source Type: news

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e Piñar Salt mines are among the most extreme environments as they combine darkness, low nutrient availability, and hypersaline conditions. Based on comparative genomics and transcriptomics, we describe in this work the adaptive strategies of the true halophilic fungus Aspergillus salisburgensis, found in a salt mine in Austria, and compare this strain to the ex-type halotolerant fungal strain Aspergillus sclerotialis. On a genomic level, A. salisburgensis exhibits a reduced genome size compared to A. sclerotialis, as well as a contraction of genes involved in transport processes. The proteome of A. sclerotialis...
Source: Genes - Category: Genetics & Stem Cells Authors: Tags: Article Source Type: research
Conclusion: OFI extracted oil has in vitro antimicrobial/fungal properties and in vivo wound healing activity. It seems to be efficient in the treatment of cutaneous infections and the promoting of the scarring process. PMID: 31097975 [PubMed]
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
This study investigated discrimination and prediction of ochratoxin A (OTA) in three Aspergillus carbonarius strains cultured grape-based medium using E-nose technology and GC-MS analysis. Results showed that these strains cultured medium samples were divided into four groups regarding their log 10 OTA value using an equispaced normal distribution analysis. Partial least squares-discriminant analysis (PLS-DA) revealed that GC-MS PLS-DA model only separated the low OTA level medium samples from the rest OTA level samples, whereas all the OTA level samples were segregated from each other using E-nose PLS-DA model. Partial le...
Source: Food Chemistry - Category: Food Science Source Type: research
Publication date: Available online 17 May 2019Source: Biocatalysis and Agricultural BiotechnologyAuthor(s): Débora Zanoni do Prado, Clarissa Hamaio Okino-Delgado, Mirella Rossitto Zanutto, Richardson Barbosa Gomes da Silva, Milene Stefani Pereira, Linda Jahn, Jutta Ludwig-Müller, Magali Ribeiro da Silva, Edvaldo Domingues Velini, Luciana Francisco FleuriAbstractCrop inoculation with microorganisms is an agricultural technique that has been used to stimulate plant growth and development by different mechanisms, such as the production of P solubilizing enzymes, the phytases, and indole-3-acetic acid (IAA). The ai...
Source: Biocatalysis and Agricultural Biotechnology - Category: Biotechnology Source Type: research
Abstract The potential antifungal activity of the marine alkaloid 2,2-bis(6-bromo-3-indolyl)ethylamine (URB 1204) was firstly assessed by minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) against different fungi. Then, URB 1204 was applied to a building material experimentally contaminated with selected fungi, in single and mixed species, for determining its potential application in preventing fungal growth. In addition, the over-time protection efficacy of URB 1204 was verified, subjecting the treated building surfaces to natural fungal contamination for 6 weeks. URB 1204 show...
Source: Applied Microbiology and Biotechnology - Category: Microbiology Authors: Tags: Appl Microbiol Biotechnol Source Type: research
Publication date: Available online 16 May 2019Source: Journal of Bioscience and BioengineeringAuthor(s): Salima Chebaibi, Mathilde Leriche Grandchamp, Grégoire Burgé, Tiphaine Clément, Florent Allais, Fatiha LaziriThe present work investigates the bioconversion of the olive cake (OC) generated by olive oil industries in Morocco through solid-state fermentation using selected filamentous fungi to increase its nutritional values for subsequent valorization as ruminants feed. The fungi, namely Beauveria bassiana, Fusarium flocciferum, Rhizodiscina cf. lignyota, and Aspergillus niger were cultured on OC fo...
Source: Journal of Bioscience and Bioengineering - Category: Biomedical Science Source Type: research
Publication date: Available online 16 May 2019Source: Pesticide Biochemistry and PhysiologyAuthor(s): Mohamed E.I. Badawy, Gehan I.Kh. Marei, Entsar I. Rabea, Nehad E.M. TaktakAbstractThe present work describes the antimicrobial action of 25 monoterpenes (six hydrocarbons, five ketones, two aldehydes, six alcohols and six acetate analogues) against Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus and antifungal activity against Aspergillus flavus. The antibacterial activity was evaluated by broth microdilution technique as a minimum inhibitory concentration (MIC) and the antifungal activity was perfor...
Source: Pesticide Biochemistry and Physiology - Category: Biochemistry Source Type: research
Journal of Natural ProductsDOI: 10.1021/acs.jnatprod.9b00055
Source: Journal of Natural Products - Category: Biochemistry Authors: Source Type: research
Publication date: August 2019Source: Phytochemistry Letters, Volume 32Author(s): Marwa Elsbaey, Chiaki Tanaka, Tomofumi MiyamotoAbstractTwo new oxoindolo diterpene epimers, anthcolorin G 1 and anthcolorin H 2, nine new meroterpenes, (7R,8R)-8-hydroxysydowic acid 4, (7S,10S)-10-hydroxy-sydowic acid 5, (7S,11R)-12-hydroxy-sydowic acid 6, (7S,11R)-12-acetoxy-sydowic acid 7, (7R,8R)-1,8-epoxy-11-hydroxy-sydonic acid 9, 7-deoxy-7,14-didehydro-11-hydroxy-sydonic acid 11, 7-deoxy-7,14-didehydro-12-acetoxy-sydonic acid 14, and (E)-7-deoxy-7,8-didehydro-12-acetoxy-sydonic acid 15, (7R)-11-hydroxy-sydonic acid methyl ester 18, and a...
Source: Phytochemistry Letters - Category: Chemistry Source Type: research
ConclusionsWe successfully established a new murine model of ECRS using more clinically relevant multiple airborne allergens. Prolonged exposure to airborne allergens for 12  weeks or more, corresponding to the definition of human ECRS, strongly induced eosinophil infiltration as well as epithelial remodeling.
Source: European Archives of Oto-Rhino-Laryngology - Category: ENT & OMF Source Type: research
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