A Novel Magnetic Nanoparticle for Early Detection of Amyloid Plaques in Alzheimer's Disease
Early diagnosis of Alzheimer's disease (AD) remains challenging even with the assistance of imaging. Radiation exposure limits the application of positron emission tomography (PET) for amyloid imaging. Magnetic resonance imaging (MRI) offers superior spatial resolution without the disadvantage of radiation exposure. We developed Mn0.6Zn0.4Fe2O4 (MZF) modified by Pittsburgh compound B (PiB) to specifically bind to amyloid plaques. Coated with amphiphilic nanopolymer 6sPCL-b-P(MEO2MA-co-OEGMA), PiB-MZF was stable, biocompatible, and approximately 100 nm in size.
Source: Archives of Medical Research - Category: Research Authors: Jiaqi Zeng, Jiaqi Wu, Minghua Li, Peijun Wang Tags: Preliminary Report Source Type: research