What is the Blood Culture Recovery Rate After Antibiotic Pretreatment?

Discussion Sepsis is an inflammatory response syndrome in the presence of an infection, it can be caused by bacteria, viruses or fungi. Bacteremia is the presence of bacteria in the blood. Studies from the US show an increased incidence of sepsis (0.56 to 0.89 cases/1000 children in all age groups) but a decreased fatality rate from 10.3% to 8.9%. The prevalence of severe sepsis in pediatric intensive care settings is reported in as many as 7.7% of admissions. Severe sepsis is more common when patients have co-morbities. Primary prevention includes immunization and appropriate precautions and procedures (i.e. catheter access) in hospitalized children or those with chronic medical needs. Prophylactic antibiotics for patients with neutropenia are also a secondary intervention. Sepsis can be difficult to diagnose in any patient and particularly in children; symptoms can be non-specific or vague. One of the biggest problems with sepsis treatment is its recognition. Body temperature may be inappropriately low or high, inappropriate tachycardia or mental status changes and reduced peripheral perfusion are clinical features of sepsis. Hypotension may not occur initially but it can also be difficult to obtain a blood pressure on a child. Mainstays of treatment are early antibiotic administration and supportive measures especially fluid resuscitation. Vasopressor medications also can help support patients. Obtaining peripheral and central access can be difficult in pediatric patients...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news

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ConclusionIn septic shock, troponin levels can be extremely high, which can persist even after recovery, as in very large myocardial infarctions.
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
Conclusion: ΔEELI
Source: Frontiers in Physiology - Category: Physiology Source Type: research
Br J Radiol. 2021 Sep 1;94(1125):20201380. doi: 10.1259/bjr.20201380.ABSTRACTOBJECTIVE: There is limited and contradictory information about pulmonary perfusion changes detected with dual energy computed tomography (DECT) in COVID-19 cases. The purpose of this study was to define lung perfusion changes in COVID-19 cases with DECT, as well as to reveal any possible links between perfusion changes and laboratory findings.METHODS: Patients who had a positive RT-PCR for SARS-CoV-2 and a contrast-enhanced chest DECT examination were included in the study. The pattern and severity of perfusion deficits were evaluated, as well as...
Source: The British Journal of Radiology - Category: Radiology Authors: Source Type: research
The spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to a devastating and worldwide pandemic disease known as coronavirus disease 2019 (COVID-19). COVID-19 causes acute hypoxic respiratory failure (COVID-ARF), a major cause of mortality and morbidity, with an incompletely understood pathophysiological mechanism. Gattinoni et al. [1] noted that COVID-19 patients with acute hypoxic respiratory failure have lung disease that is often characterised by a remarkable dissociation between relatively well-preserved lung mechanics, including lung compliance, and severe hypoxaemia. These findings are con...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Original Articles: Research letters Source Type: research
CONCLUSION: This study highlights the cumulative risk associated with ethnicity and renal disease in predicting short-term outcomes following CABG. This warrants further investigations in larger populations, thus guiding pre-operative risk-stratification.PMID:34365853 | DOI:10.1177/02676591211037577
Source: Perfusion - Category: Cardiovascular & Thoracic Surgery Authors: Source Type: research
Conclusions: Single intravenous dose of 2mg/kg of XAV-19 demonstrated high serum concentrations, predictive of potent durable neutralizing activity with good tolerability. Trial registration: ClinicalTrials.gov Identifier: NCT04453384.PMID:34181475 | DOI:10.1128/AAC.01237-21
Source: Antimicrobial Agents and Chemotherapy - Category: Microbiology Authors: Source Type: research
Conclusions: The COVID-19 pandemic has forced medical institutions and health care systems all over the world to adapt to a rapidly changing environment with the challenge to deliver high quality health care while minimizing risk to staff and patients alike. This has presented a unique problem requiring both flexibility and innovativeness. Furthermore, there are the logistical challenges in policy implementation which are proportionally increased the larger the system is. Aerosol-generating procedures, such as ventilation scanning, inherently increase the risk of virus spread. The incorporation of SPECT or SPECT/CT with Tc...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Diagnostic & amp; Therapeutic Nuclear Medicine and Instrumentation amp; Data Analysis Source Type: research
Conclusions: The overall quantity of lung examinations for PE slightly diminished between March 1st and June 30th of 2020 comparing to same time period in 2019. More than two-thirds of CTPA and almost half of VQ were performed in subjects with COVID suspicion. However, referrals for CTPA and VQ remained possible as demonstrated by the similarities in the demographics and location of patients (inpatient, outpatient, emergency) to the same time period in 2019. Despite of COVID-19, the positive rate of PE observed in 2020 was identical to 2019, for both CTPA or VQ.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Infectious Disease/Pulmonary/Outcomes Source Type: research
Conclusions: The COVID-19 pandemic has forced medical institutions and health care systems all over the world to adapt to a rapidly changing environment with the challenge to deliver high quality health care while minimizing risk to staff and patients alike. This has presented a unique problem requiring both flexibility and innovativeness. Furthermore, there are the logistical challenges in policy implementation which are proportionally increased the larger the system is. Aerosol-generating procedures, such as ventilation scanning, inherently increase the risk of virus spread. The incorporation of SPECT or SPECT/CT with Tc...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Integral Role of imaging in the Management of Covid-19 Patients Source Type: research
Conclusions: In the wake of COVID-19 pandemic, ventilation scintigraphy carries an inherent risk of COVID-19 exposure to the imaging personnel. However, the lung perfusion scintigraphy with added SPECT/CT imaging serves to overcome the deficiency of ventilation imaging. This exhibit illustrates the common and uncommon perfusion and computed tomography lung findings in those patients who recovered from COVID-19 infection and continue to be symptomatic, requiring supportive therapy. The knowledge of these findings will help the readers in interpreting the clinical and laboratory findings and correlate it with the lung perfus...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: General Clinical Specialties Source Type: research
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