Oxidative, inflammatory and cardiometabolic biomarkers of clinical relevance in patients with metabolic syndrome

Conclusion: The combination of IL-6, ultra-sensitive C-reactive protein (us-CRP), ADA, DPP-IV and the increase of TBARS, with the reduction of vitamin C, SH groups and adiponectin, promote inflammation and compromise insulin sensitivity, thus presenting an active role in the pathogenesis of MetS. These findings are significant because they may assist in monitoring clinical changes, in the prevention of future cardiometabolic events in individuals with MetS, and in the identification of inflammatory and oxidative markers that assist in the monitoring and prevention of MetS.RESUMO Introdu ção: A obesidade caracteriza-se pela deposição excessiva de gordura no tecido adiposo e está associada ao desenvolvimento de danos patológicos em vários processos metabólicos que estão relacionados com o estresse oxidativo e a inflamação. Objetivo: Avaliar os níveis de adiponectina, mar cadores inflamatórios e marcadores oxidativos, com o objetivo de determinar um perfil de biomarcadores em adultos que influencie o risco metabólico de desenvolver síndrome metabólica (SMet). Métodos: Os grupos estudados incluíram 84 adultos (48 sem SMet e 36 com SMet). Parâmetros gerais e bi oquímicos foram determinados. Níveis de adiponectina, marcadores inflamatórios [proteína C reativa ultrassensível (PCR-us), interleucina 6 (IL-6), adenosina d...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - Category: Pathology Source Type: research

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Conclusions. The prevalence of metabolic syndrome observed among the study population was 90.6%, with a higher percentage in females than males. High triglyceride levels and high waist circumference were the main risk factors for MS in the diabetic population. PMID: 31187045 [PubMed - in process]
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
CONCLUSIONS: Insufficient riboflavin intake may contribute to development of cardiometabolic disorder, particularly in women. It was also found that riboflavin may have different influences on its risks in women according to menopausal status. This study highlighted the importance of public policies targeted at these sex-specific groups for reducing cardiometabolic risks. PMID: 31192558 [PubMed - in process]
Source: Asia Pacific Journal of Clinical Nutrition - Category: Nutrition Authors: Tags: Asia Pac J Clin Nutr Source Type: research
ConclusionThe prevalence of MetS is increasing in Young female university in the KSA as a result of an unhealthy lifestyle, including a lack of physical activity, leading to increased weight and the possible development of chronic diseases.
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - Category: Endocrinology Source Type: research
CONCLUSIONS: There is a correlation between the waist circumference and metabolic risks among non-obese populations, but the screening for metabolic diseases should be conducted among males with a waist circumference of over 78 cm and females with a waist circumference of over 74 cm. The treatment measures are supposed to be taken promptly to improve the prognosis. PMID: 31173313 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Authors: Choromanska B, Mysliwiec P, Hady HR, Dadan J, Mysliwiec H, Bonda T, Chabowski A, Miklosz A Abstract Obesity is characterised by imbalance in lipid metabolism manifested by high concentrations of circulating triacylglycerols and total cholesterol as well as low high-density lipoprotein (HDL) levels. Abnormalities related to these lipids lead to metabolic complications such as type 2 diabetes, arterial hypertension and cardiovascular disease. Despite extensive research, it is still unclear why a subset of obese subjects develop metabolic syndrome, while others do not. The aim of our work was to assess total ...
Source: Journal of Physiology and Pharmacology - Category: Drugs & Pharmacology Tags: J Physiol Pharmacol Source Type: research
Discussion and conclusionYWHAZ could be a new important regulator of capacitation ‐associated tyrosine phosphorylation and a marker of dyslipidemia‐induced infertility.
Source: Andrology - Category: Urology & Nephrology Authors: Tags: Supplement Source Type: research
ConclusionsWe reported high frequency of hypertriglyceridemia and low HDL in Mexican children. TyG and TG/HDL are good predictors for IR. TyG has a better diagnostic accuracy. We need implementing TyG for identifying alterations and intervening in a timely manner to delay the onset of chronic diseases in children.
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - Category: Endocrinology Source Type: research
AbstractBackgroundOverweight and obesity were recently associated with a poor prognosis in patients with autosomal dominant polycystic kidney disease (ADPKD). Whether the metabolic consequences of obesity as defined by the metabolic syndrome (MS) are also linked with disease progression remains untested.MethodsEligible ADPKD patients with different stages of CKD (n = 105) and 105 non-diabetic controls matched for CKD stage were enrolled in the study. Groups were evaluated at baseline for presence of MS, blood markers of metabolism, homeostasis model assessment of insulin resistance (HOMA-IR) score, and bioche...
Source: Clinical and Experimental Nephrology - Category: Urology & Nephrology Source Type: research
Authors: Imga NN, Karci AC, Oztas D, Berker D, Guler S Abstract Introduction: Vitamin D deficiency is a common problem, and it is related to increased risk of obesity, metabolic syndrome, atherosclerosis, and cardiovascular disease. Vitamin D has a beneficial effect on dyslipidemia and insulin secretion. We aimed to investigate the impact of vitamin D3 supplementation on anthropometric and laboratory parameters in overweight and obese premenopausal women. Material and methods: Seventy-two overweight and 50 obese vitamin-D-deficient premenopausal women (mean age: 43.1 ±10.4 years) were included in the stu...
Source: Archives of Medical Science - Category: General Medicine Tags: Arch Med Sci Source Type: research
438Objectives: Brown adipose tissue (BAT) plays a key role in energy homeostasis, conferring protection against diet-induced obesity, and has even been suggested as a potential target for the treatment of obesity and metabolic syndrome. The purpose of this study was to compare the metabolic outcomes (lipid profile and diabetes) of patients with and without BAT activity on FDG PET/CT, which remains the golden standard for visualization of BAT. Methods: PET/CT exams from 1834 breast cancer patients were retrospectively reviewed for bilateral symmetric elongated FDG activity in the neck and chest, typical of BAT activation. B...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: NETs, BAT and All That Source Type: research
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