The next generation in detection of leukemia-associated translocations

Diagnosis of leukemia has come a long way since the days of the French-American-British classification scheme, which relied upon a combination of blast counts, morphology, and cytochemistry to classify myeloid and lymphoid acute leukemias (1). Beginning with the 2008 World Health Organization (WHO) Classification of Tumors of the Hematopoietic and Lymphoid Tissues (2) and expanded in the 2017 edition (3), new categories of acute myeloid leukemia and acute lymphocytic leukemia were created based solely on molecular abnormalities present within the leukemic cells, independent of the proportion of leukemic blasts in the peripheral blood or bone marrow.
Source: Journal of Molecular Diagnostics - Category: Pathology Authors: Tags: Commentary Source Type: research