Resistance to Fas-Mediated Apoptosis Does Not Correlate to Structural Alterations or Expression Changes of the Death Receptor in Papillary Thyroid Carcinomas

Conclusions: Our results denote thatFAS death domain orTP53 DNA-binding domain mutations, down-regulation of FAS receptor expression, or expression ofFAS soluble isoform are not responsible for the seeming inhibition of FAS-mediated apoptosis in papillary thyroid carcinoma cells.Pathobiology
Source: Pathobiology - Category: Pathology Source Type: research