Association between serotonin –norepinephrine reuptake inhibitors and acute angle closure: what is known?

Serotonin-norepinephrine reuptake inhibitors (SNRIs) are widely used antidepressants with a relatively safe profile. One of the complications associated with this group of drugs is acute angle closure (AAC). The mechanisms linking SNRIs and AAC are complex and may be interlinked with the effects of the drug on the inhibition of serotonin and noradrenaline reuptake, as well as pseudo-anticholinergic effects, dopaminergic effects, and idiosyncratic reactions with the drug molecule in the eye. Individual characteristics, such as polymorphisms of the gene encoding the 2D6 subunit of cytochrome P450, may affect the metabolism of the SNRI; while, the combination with other drugs may lead to an increased risk of iridocorneal angle closure, and may further exacerbate other mechanisms.

Source: Survey of Ophthalmology - September 29, 2018 Category: Opthalmology Authors: M. Wici ński, B.J. Kałużny, S. Liberski, D. Marczak, M. Seredyka-Burduk, K. Pawlak-Osińska Tags: Review in medicine Source Type: research