Liver lipid metabolism disruption in cancer cachexia is aggravated by cla supplementation -induced inflammation

The liver is the main organ regulating metabolism. In spite of that, few studies examine liver metabolism in cachexia, a wasting syndrome associated with increased morbidity and mortality in cancer. Cachexia induces major metabolic disruption, inflammation and fat and lean mass loss. We have previously shown impairment of hepatic lipid metabolism in cancer cachexia that contributes to the aggravation of the symptoms. The present study addresses the effects of Conjugated Linoleic Acid supplementation upon liver lipid metabolism in cachectic rats.

Source: Clinical Nutrition - October 1, 2018 Category: Nutrition Authors: Daniela Caetano Gon çalves, Fábio Santos Lira, Alex Shimura Yamashita, Luiz Carlos Carnevali Junior, Robson Eder, Alessandro Laviano, Marília Seelaender Tags: Original article Source Type: research