Variants of the OLIG2 Gene are Associated with Cerebral Palsy in Chinese Han Infants with Hypoxic –Ischemic Encephalopathy

In this study, we employed a Chinese Han cohort of 763 CP infants and 738 healthy controls to study the association ofOLIG2 gene polymorphisms with CP. We found marginal association of the SNP rs6517135 with CP (p = 0.044) at the genotype level, and the association was greatly strengthened when we focused on the subgroup of CP infants who suffered from hypoxic–ischemic encephalopathy (HIE) after birth, withp = 0.003 (OR = 0.558) at the allele level andp = 0.007 at the genotype level, indicating a risk-associated role of the T allele of the SNP rs6517135 under HIE conditions. The haplotype CTTG for rs6517135–rs1005573–rs6517137–rs9653711 inOLIG2 was also significantly associated with the occurrence of CP in infants with HIE (p = 0.01, OR = 0.521). Our results indicate that in the Han Chinese population, the polymorphisms ofOLIG2 were associated with CP, especially in patients who had suffered HIE injury. This finding could be used to develop personalized care for infants with high susceptibility to CP.
Source: NeuroMolecular Medicine - Category: Neurology Source Type: research