Modifying Rap1-signalling by targeting Pde6 δ is neuroprotective in models of Alzheimer’s disease

Neuronal Ca2+ dyshomeostasis and hyperactivity play a central role in Alzheimer ’s disease pathology and progression. Amyloid-beta together with non-genetic risk-factors of Alzheimer’s disease contributes to incre...

Source: Molecular Neurodegeneration - September 26, 2018 Category: Neurology Authors: Michael Dumbacher, Tom Van Dooren, Katrien Princen, Koen De Witte, M élissa Farinelli, Sam Lievens, Jan Tavernier, Wim Dehaen, Stefaan Wera, Joris Winderickx, Sara Allasia, Amuri Kilonda, Stéphane Spieser, Arnaud Marchand, Patrick Chaltin, Casper C. Hoo Tags: Research article Source Type: research