V-Wave launches pivotal interatrial shunt trial

V-Wave said today it launched a new trial of its minimally invasive interartrial shunt designed to treat patients with symptomatic heart failure. The new Relieve-HF trial aims to enroll 500 patients in a pivotal study of the device, which is designed for patients with NHYA Class III and ambulatory Class IV symptomatic heart failure, the Israel-based company said. “The interatrial shunt provides a novel therapeutic approach for patients with chronic HF. The shunt is implanted through a catheter inserted in a vein in the leg. Prior clinical experience demonstrated device and implantation procedure safety, and statistically significant improvements in symptoms, quality of life measurements, and exercise capacity were observed compared to a matched population receiving optimal care. We are fortunate to have our study designed by the world’s leading HF clinical trialists: Drs. William Abraham from the Ohio State University, Gregg Stone, from Columbia University, JoAnn Lindenfeldof Vanderbilt University, Stefan D. Anker from Charité Berlin, Germany, and Josep Rodés-Cabau, MD, Laval University, Quebec.  These extraordinary physicians have planned and executed some of the most influential and successful HF and structural heart disease device trials,” CEO Dr. Neal Eigler said in a press release. V-Wave said that it has enrolled two patients in the study so far, and that both were...
Source: Mass Device - Category: Medical Devices Authors: Tags: Cardiovascular Clinical Trials V-Wave Source Type: news

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In conclusion, this is the first report to show that pyroptotic cell death occurs in the aging brain and that the inflammasome can be a viable target to decrease the oxidative stress that occurs as a result of aging. Reducing Levels of Protein Manufacture Slows Measures of Aging in Nematodes https://www.fightaging.org/archives/2018/12/reducing-levels-of-protein-manufacture-slows-measures-of-aging-in-nematodes/ Researchers here demonstrate that an antibiotic slows aging in nematode worms, providing evidence for it to work through a reduction in protein synthesis. Beyond a slowing of aging, one of the con...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Pediatric heart transplantation is considered a standard therapy for end-stage heart failure refractory to medical and surgical therapy.1 Since its inception in 1967, heart transplant use has continually increased with expansion to more complex populations.2,3 A recent International Society of Heart and Lung Transplantation (ISHLT) report evaluated post-transplant outcomes among different transplant indications and found that despite ongoing improvement in overall pediatric transplant survival, there remains a persistent survival advantage for dilated cardiomyopathy compared to congenital heart disease (CHD) and re-transplantation.
Source: Journal of Cardiac Failure - Category: Cardiology Authors: Tags: Clinical Investigation Source Type: research
Despite the numerous innovations in all diagnostic and treatment aspects of congenital heart disease, the management of pulmonary vein stenosis (PVS), primary or postoperative, continues to be perplexing and 1-2 year survival of patients with progressive PVS seems to have stubbornly plateaued at a low range of 50-60%.1-4 Various medical, percutaneous and surgical treatment modalities for PVS have been described. Nonetheless, all those options continue to be associated with inferior outcomes due to residual lesions, recurrent stenosis secondary to disease progression in the same or other pulmonary veins, development of pulm...
Source: Seminars in Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: Congenital – Editorial Commentary Source Type: research
Conclusions: Prognosis was poor and comorbidity burden was substantial in the cohort of patients with PF and subcohort with IPF.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Rare ILD/DPLD Source Type: research
ConclusionPatients who are at risk for SCA are patients who have had a cardiac arrest due to ventricular fibrillation (VF) or sustained ventricular tachycardia (SVT), those with familial or inherited condition with sudden cardiac arrest risk, myocardial infarction with an ejection fraction (EF) of less than or equal to 35%, dilated cardiomyopathy (including NICM), with an EF of less than or equal to 35%, ICD explanations, and other conditions with high risk of ventricular tachycardia (VT) or VF are candidates for the WCD.The sample of data was from 186 patients. However, more patients were likely candidates but may not hav...
Source: Heart and Lung: The Journal of Acute and Critical Care - Category: Respiratory Medicine Source Type: research
Eighty five percent of congenital heart disease patients currently survive to adulthood due primarily to advancements in surgical treatments1. For these survivors with Adult Congenital Heart Disease (ACHD), heart failure (HF) remains the leading cause of death2. Thus, the number of ACHD patients requiring heart transplantation (HT) continues to grow, and with this growth has come improvements in outcomes. In 2009, Lamour et al. demonstrated a 1-year survival of 83% for non-Fontan congenital HT and 71% for patients with Fontan palliation3.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: Original Clinical Science Source Type: research
In this study, we investigate mitochondrial energetics and mtDNA methylation in senescent cells, and evaluate the potential of humanin and MOTS-c as novel senolytics or SASP modulators that can alleviate symptoms of frailty and extend health span by targeting mitochondrial bioenergetics. Exercise versus the Hallmarks of Aging https://www.fightaging.org/archives/2018/06/exercise-versus-the-hallmarks-of-aging/ The paper I'll point out today walks through the ways in which exercise is known to beneficially affect the Hallmarks of Aging. The Hallmarks are a list of the significant causes of aging that I dis...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
In conclusion, a debate exists on whether aging is a disease in itself. Some authors suggest that physiological aging (or senescence) is not really distinguishable from pathology, while others argue that aging is different from age-related diseases and other pathologies. It is interesting to stress that the answer to this question has important theoretical and practical consequences, taking into account that various strategies capable of setting back the aging clock are emerging. The most relevant consequence is that, if we agree that aging is equal to disease, all human beings have to be considered as patients to be treat...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Right ventricular (RV) is a key driver of outcome in heart failure and pulmonary vascular disorders. Although the RV fails in response to an increased afterload, it has been shown to be affected in patients with left heart diseases in the absence of pulmonary hypertension (PH). Therefore, it is recommended to consider the RV and the pulmonary artery (PA) as a single unit, defined physiologically by RV-PA coupling. The aim of this study is to assess whether non-invasive RV-PA coupling may predict outcome in PAH and in LHD.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
We describe the design and rationale of a prospective multicenter registry aimed at collecting clinical data to be compared with retrospective control data to measure changes in outcomes and utility for surgeons when 3D printed models are used for planning VAD placement.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
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