Combined use of Quantiferon and HBHA-based IGRA supports tuberculosis diagnosis and therapy management in children

Interferon- γ release assays (IGRA) are designed for diagnosis of tuberculosis (TB) infection, and do not discriminate latent TB infection (LTBI) from active TB. Heparin-binding hemagglutinin antigen (HBHA) emerged as a promising antigen for TB diagnosis when used in IGRA format. Aim of this study was to prosp ectively evaluate the performance of an HBHA-based IGRA to support TB diagnosis and TB therapy monitoring in children with TB infection or active TB disease.

Source: Journal of Infection - September 26, 2018 Category: Infectious Diseases Authors: Michela Sali, Danilo Buonsenso, Pamela D'Alfonso, Flavio De Maio, Manuela Ceccarelli, Basem Battah, Ivana Palucci, Teresa Chiacchio, Delia Goletti, Maurizio Sanguinetti, Piero Valentini, Giovanni Delogu Source Type: research