Adapting medical guidelines to be patient-centered using a patient-driven process for individuals with sickle cell disease and their caregivers
ConclusionsIndividuals with SCD and their caregivers want access to guidelines through multiple channels, including technology. Guidelines written for health care providers can be adapted to be patient-centered using Community-engaged research involving providers and patients. These patient-centered guidelines provide a framework for patients to discuss their medical care with their health care providers.
Sickle cell anemia, the most common form of sickle cell disease (SCD) is caused by the homozygous mutation in the β-globin gene, which leads to erythrocyte sickling, impaired rheology, vaso-occlusion and premature hemolysis6. Vaso-occlusion and hemolysis are the two predominant pathophysiological events in SCD that contribute to chronic organ damage and acute systemic painful vaso-occlusive episode (VOE)3,6. E arlier, we have shown that VOE involves entrapment of large neutrophil-platelet aggregates in lung arterioles of SCD mice, which is inhibited following IV administration of P-selectin function blocking antibody5.
Postoperative vaso ‐occlusive disease may be a life‐threatening condition in patients affected by sickle cell disease, necessitating sometimes liver transplantation. After laparoscopic cholecystectomy, liver necrosis is usually secondary to intraoperative vascular injury. In this patient, the vaso‐occlusive cris is mimicked a vascular injury with segmental postoperative necrosis. AbstractPostoperative vaso ‐occlusive disease may be a life‐threatening condition in patients affected by sickle cell disease, necessitating sometimes liver transplantation. After laparoscopic cholecystectomy, liver necrosis is usually s...
We present a case of rmc including radiologic and pathology findings, treatment, and outcome. A review of the literature is also presented, with an emphasis on the association of rmc with sickle cell trait, which was an unknown diagnosis in our patient preoperatively. PMID: 32218668 [PubMed - as supplied by publisher]
We present a new method to obtain erythrocyte shape classification using peripheral blood smear sample images. The aim of the method is to segment the cells, to separate clusters and classify cells (circulars, elongated and others). We compared our method with state-of the-art. Results showed that our method with is superior for the diagnosis support of sickle cell anemia.
Date: April 6, 2020 Issue #: 1595Summary: The FDA has approved two new drugs for sickle cell disease: crizanlizumab-tmca (Adakveo– Novartis), an IV P-selectin blocker, and voxelotor (Oxbryta– GBT), an oral hemoglobin S (HbS) polymerization inhibitor.
The study aimed to evaluate the effect of progressive muscle relaxation exercises on pain in patients with sickle cell disease.
Floyd Rohan Not only do racial and ethnic minority children and adolescents with chronic illness experience disparities in health status and health outcomes, they also experience significant healthcare disparities, including differences in healthcare coverage, access to care, and quality of care. It is well known that the interaction between psychosocial functioning, health behaviors and ethnic and racial disparities, ultimately leads to worse health and psychosocial outcomes in pediatric and AYA chronic illness patient populations, including increased rates of morbidity and mortality. Investigating the impact of ra...
AbstractBackgroundSickle cell nephropathy (SCN) is a progressive disease that contributes significant morbidity and mortality in sickle cell disease (SCD), yet it remains poorly understood. Hyperuricemia negatively impacts renal function in the non-sickle cell population but is understudied in SCD.MethodsWe performed a cross-sectional analysis of the first 78 pediatric SCD patients enrolled in a cohort study. The mechanism of development of hyperuricemia (defined, serum uric acid (UA) ≥ 5.5 mg/dL) was characterized as a result of either UA overproduction or inefficient renal excretion by the Simkin index and fractional ...