Experimental folate deficiency in human subjects: what is the influence of vitamin C status on time taken to develop megaloblastic anaemia?

ConclusionBecause of the importance of folate in one-carbon metabolism, the potential influence of vitamin C intake on the time taken to deplete the liver folate store should be experimentally investigated.
Source: BMC Hematology - Category: Hematology Source Type: research

Related Links:

ConclusionsVitamin B12 levels should be considered during differential diagnosis of neurological symptoms in exclusively breast-fed infants especially if they co-exist with megaloblastic anemia and psychomotor retardation.
Source: Italian Journal of Pediatrics - Category: Pediatrics Source Type: research
The case of thiamine ‐responsive megaloblastic anemia (TRMA) presented here speculates the need early diagnosis, continuous monitoring, follow‐up, and regulated treatment plan for the patients. Complications and systemic manifestations are likely to enhance in otherwise circumstances. AbstractThe case of thiamine ‐responsive megaloblastic anemia (TRMA) presented here speculates the need early diagnosis, continuous monitoring, follow‐up, and regulated treatment plan for the patients. Complications and systemic manifestations are likely to enhance in otherwise circumstances.
Source: Clinical Case Reports - Category: General Medicine Authors: Tags: CASE REPORT Source Type: research
We report a child presenting with TMA features with cobalamin deficiency. Because of her family history of vitamin B12 deficiency and proteinuria, the performed genetic analysis revealed that an Imerslund-Gräsbeck Syndrome with the detection of a homozygous mutation in AMN gene. PMID: 32045704 [PubMed - as supplied by publisher]
Source: European Journal of Medical Genetics - Category: Genetics & Stem Cells Authors: Tags: Eur J Med Genet Source Type: research
ConclusionThe diagnosis of TRMA should be kept in mind in differential diagnosis of DM with anemia and or sensorineural hearing loss. Particularly in the populations where the consanguinity is frequent as diagnosis has great impact on management.
Source: International Journal of Diabetes in Developing Countries - Category: Endocrinology Source Type: research
Publication date: Available online 22 January 2020Source: Process BiochemistryAuthor(s): Bhawna Batra, Vinay Narwal, Vijay Kalra, Minakshi Sharma, JS RanaAbstractFolic acid (FA) also known as (N-[p-{[(2-amino-4-hydroxy-6-pteridinyl) methyl] amino} benzoyl]-l-glutamic acid), is a water soluble vitamin found in plants and animals. The deficiency of FA leads to an increased risk of various diseases like neural tube defects in newborn, cardiovascular disease, cancer, Alzheimer’s disease and megaloblastic anemia. The normal levels of FA in human blood serum should fall in the range between 2 and 15 ng/mL. Present r...
Source: Process Biochemistry - Category: Biochemistry Source Type: research
Priyanka Madaan, Prashant Jauhari, Shruthi N Michael, Aditi Sinha, Biswaroop Chakrabarty, Sheffali GulatiAnnals of Indian Academy of Neurology 2020 23(1):136-138
Source: Annals of Indian Academy of Neurology - Category: Neurology Authors: Source Type: research
Conclusion: Our case emphasizes the diagnostic challenges of HLH, in a patient with EBV infection whose evolution was hindered by a severe epistaxis, with potentially fatal outcome.
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
Authors: Fukuda H, Takekuma M, Hirashima Y Abstract A 62-year-old Japanese woman developed numbness of the extremities and megaloblastic anemia. She had undergone total abdominal hysterectomy, whole-pelvis radiation therapy and chemotherapy for gynecological cancer 10 years before. Chronic abdominal pain, diarrhea and intermittent small-bowel obstruction had afflicted her for a long time. We diagnosed her with vitamin B12 deficiency anemia and polyneuropathy due to chronic radiation enteritis causing malabsorption. Vitamin B12 injections improved her numbness and anemia. The early diagnosis and treatment of deficie...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
We present a case report of a 29-year-old woman where these laboratory findings are described.
Source: Hematology Oncology and Stem Cell Therapy - Category: Cancer & Oncology Source Type: research
AbstractAnemia associated with alcoholism has numerous causes, most common being megaloblastic anemia and acquired sideroblastic anemia (SA). The bone marrow aspirate (BMA) and bone marrow iron (BMIr) findings and their correlation with peripheral blood smear (PBS) have not been extensively described in literature. We aim to study the spectrum of hematological abnormalities in chronic alcoholics. Complete blood count (CBC), PBS, BMA and BMIr of 71 chronic alcoholics were studied retrospectively over a period of 3  years. The slides were reviewed by 2 pathologists. The clinical history, CBC, PBS, BMA and BMIr findings ...
Source: Indian Journal of Hematology and Blood Transfusion - Category: Hematology Source Type: research
More News: Anemia | Diets | Folic Acid | Hematology | Liver | Megaloblastic Anemia | Nutrition | Urology & Nephrology | Vegetarian | Vitamin B9 | Vitamin C | Vitamins