Hematological profile of pregnant women at St. Paul ’s Hospital Millennium Medical College, Addis Ababa, Ethiopia
This study aimed to assess hematological profiles of pregnant women at a tertiary care teaching hospital.MethodThis cross sectional study was conducted among 284 consecutive pregnant women at St. Paul ’s Hospital Millennium Medical College. Socio-demographic characteristics were collected using pre-tested structured questionnaire. About 4 ml of venous blood was collected from each participant for hematological parameters analysis using Cell-Dyn1800 (Abbott Laboratories Diagnostics Division, US A) and peripheral blood film review.ResultThere were differences in mean hematological parameters between trimesters: specifically differences in mean values of WBC (1stand 3rd), Hb(1stand2nd and 1st&3rd), HCT (1stand2nd), RDW (1stand2nd and 1stand3rd), neutrophil and lymphocyte (1stand 2nd and 1stand3rd, for both) were statistically significant (p
Authors: Andrade C Abstract Many observational studies have found an association between antidepressant drug prescription during pregnancy and neurodevelopmental disorders such as autism spectrum disorder, attention-deficit/hyperactivity disorder, and intellectual disability. The results of such studies cannot be considered conclusive because of the possible presence of inadequately measured, unmeasured, and unknown confounds. In this context, maternal anemia before or at but not after 30 weeks of gestation was recently associated with an increased risk of all 3 of these neurodevelopmental disorders. Additionally, ...
Conclusion: These finds highlight the role of ERAP1 in the pathogenesis of preeclampsia. PMID: 32239976 [PubMed - as supplied by publisher]
Publication date: Available online 3 April 2020Source: Journal of Solid State ChemistryAuthor(s): Ju Guo, Mei Yu, Fuyong Wu
Phys. Chem. Chem. Phys., 2020, Accepted Manuscript DOI: 10.1039/D0CP00791A, PaperXuan Zhang, Zikuan Wang, Jun Gao, Wenjian Liu The selectivity of halogenation versus hydroxylation in α-KG de-pendent halogenases is vital to their function and has been widely studied, particularly using the halogenase SyrB2 as a model. WelO5, a... The content of this RSS Feed (c) The Royal Society of Chemistry
Chem. Commun., 2020, Advance Article DOI: 10.1039/C9CC09563B, CommunicationKostadin V. Petrov, Laura Paltrinieri, Lukasz Poltorak, Louis C. P. M. de Smet, Ernst J. R. Sudh ölter A novel ion separation methodology using a cation-exchange membrane modified with iron oxide nanoparticles (Fe3O4 NPs) coated with polyhexamethylene guanidine (PHMG) is proposed. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
CONCLUSIONS: Low RBC folate is associated with perinatal factors, including high maternal cotinine levels, body mass index, stress, and depression. The effect of low folate levels among smokers cannot be overemphasized, considering that tobacco products not only reduce folate levels but also decrease the bioutilization of folate. PMID: 32239227 [PubMed - as supplied by publisher]
ConclusionDispensing of potentially harmful medicines in pregnancy in New Zealand was low, particularly for Category X medicines. However, exposure did increase over the study timeframe. The inclusion of pregnancies that did not progress past early pregnancy better reflects population-level pregnancy exposure to potentially teratogenic medicines.
AbstractThese are the results of phase II study of bortezomib-melphalan-prednisolone (VMP) induction therapy followed by lenalidomide-dexamethasone (Rd) consolidation and lenalidomide maintenance in transplant-ineligible patients with newly diagnosed multiple myeloma (NDMM). The primary end point was progression-free survival (PFS). Secondary end points included overall survival (OS), overall response rates (ORRs), and safety. Eighty-three eligible patients were enrolled between October 2012 and August 2014. The median PFS was 28.0 months (95% CI 19.6–36.7) and the median OS was 55.3 months (95% CI 51.6&nd...
Authors: Gallo L, Ruggiero A, Balato A, Megna M, Fabbrocini G PMID: 32233899 [PubMed - as supplied by publisher]
Complement-mediated thrombotic microangiopathy (TMA), also known as atypical hemolytic uremic syndrome (aHUS) is a rare, hereditary, progressive, life-threatening disorder caused by a disruption in regulation of the alternative pathway of the complement system. Eculizumab, a terminal complement inhibitor, has emerged as a first-line therapy, however data are limited to small case series (Brocklebank et al., 2017). Here, we present a diagnostically challenging case of complement-mediated TMA, who received eculizumab therapy with excellent hematologic response.A 68-year-old female with history of possible Sjogren's syndrome,...