A Typical Presentation of Tuberculosis in Cirrhosis

A 44-year old woman with Child –Pugh A cirrhosis presented with large-volume ascites. Laboratory indices showed an international normalized ratio of 1.7, a bilirubin level of 90 umol/L, WCC of 8.4 × 109/L, and an albumin level of 29 g/dL. Ascitic fluid analysis showed a WCC of 35 cells/mm3, culture and cytology were negative, and the serum albumin-ascites gradient was 9 g/dL. Cross-sectional imaging showed no hepatocellular carcinoma or pathologic lymphadenopathy. A computed tomography–positron-emission tomography scan (Figure A) showed intense uptake of a thickened peritoneum consistent with a metabolically active process.
Source: Clinical Gastroenterology and Hepatology - Category: Gastroenterology Authors: Tags: Image of the Month Source Type: research

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We report a case of invasive mucormycosis in 52 year-old woman. CT-scan and magnetic resonance imaging found a partial right sinus thrombosis associated with homolateral ethmoidal and maxillary sinusitis with submucosal inflammation. Histopathological examination of excised tissue was positive for mucormycosis. Our patient was treated by surgical debridement and a combination of amphotericin B and caspofungin, with a good outcome.
Source: Medical Mycology Case Reports - Category: Biology Source Type: research
Publication date: 25 January 2020Source: Journal of Alloys and Compounds, Volume 814Author(s): Thirupathi Gadipelly, Arup Dasgupta, Chanchal Ghosh, Vaishnavi Krupa, D. Sornadurai, Binaya Kumar Sahu, Sandip DharaAbstractIn the present work, we established an ex-situ procedure to synthesize Y2Ti2O7 nanopowder using the microwave-hydrothermal technique followed by conventional calcination treatment. This powder is otherwise synthesized by in-situ through a reaction between Y2O3 and Ti in a steel matrix for the production of oxide dispersion strengthened (ODS) steels. The hydrothermal synthesis was involved of chemical reactio...
Source: Journal of Alloys and Compounds - Category: Chemistry Source Type: research
Publication date: Available online 21 September 2019Source: European Polymer JournalAuthor(s): Tatiya Trongsatitkul, Clara Jiménez-Saelices, Bruno Pontoire, Isabelle Capron, Denis LourdinAbstractStarch films containing eicosane droplets with diameters of 3-5 μm homogeneously distributed over the thickness were prepared using the casting method. The films also contain a quantity of water (4 to 22%) depending on the relative humidity during conditioning (from 7% to 90%, respectively). The calorimetric behavior of dispersed eicosane droplets, studied by Differential Scanning Calorimetry, shows a shift in the melting...
Source: European Polymer Journal - Category: Chemistry Source Type: research
Publication date: Available online 22 August 2019Source: The Journal of Molecular DiagnosticsAuthor(s): Sally E. Trabucco, Kyle Gowen, Sophia L. Maund, Eric Sanford, David A. Fabrizio, Michael J. Hall, Evgeny Yakirevich, Jeffrey P. Gregg, Phil J. Stephens, Garrett M. Frampton, Priti S. Hegde, Vincent A. Miller, Jeffrey S. Ross, Ryan J. Hartmaier, Shih-Min A. Huang, James X. SunMicrosatellite instability (MSI) is an important biomarker for predicting response to immune checkpoint inhibitor therapy, as emphasized by the recent checkpoint inhibitor approval for MSI-high (MSI-H) solid tumors. Herein, we describe and validate a...
Source: The Journal of Molecular Diagnostics - Category: Pathology Source Type: research
Publication date: Available online 21 September 2019Source: Pathology - Research and PracticeAuthor(s): Rahul Mannan, Alexander S. Taylor, Daniel E. Spratt, Arul M. Chinnaiyan, Jeffrey S. Montgomery, Noah A. Brown, Rohit MehraAbstractBladder cancer continues to be a source of disease burden worldwide. In patients with a long-standing history of prostate cancer, distinguishing between new/independent and synchronous poorly differentiated urothelial carcinoma (UCA) and residual/recurrent high grade/poorly differentiated prostatic adenocarcinoma or prostatic adenocarcinoma with therapy-related changes can be diagnostically an...
Source: Pathology Research and Practice - Category: Pathology Source Type: research
Conclusion: In conclusion, liver cirrhosis is the major cause of ascites in Gondar, Ethiopia, while chronic viral hepatitis infections (hepatitis B (HBV) and C (HCV) viruses) are the main causes of liver cirrhosis. The other major causes included heart failure, tuberculosis, and hepatosplenic schistosomiasis. It is wise to consider and give priority to these diseases whenever one is evaluating a patient with ascites. PMID: 31360695 [PubMed - in process]
Source: Canadian Journal of Gastroenterology - Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research
Introduction: Peritoneal angiosarcoma is an extremely rare sarcoma (0.01287% incidence per 100,000) with an aggressive course and a poor prognosis. In this case, the manifestation of peritoneal angiosarcoma was ascites, which caused difficulty in early diagnosis and the diagnosis of peritoneal angiosarcoma, was made only after the surgery. Patient concerns: A 61-year-old man working in Mainland China presented with a 1-month history of abdominal distension. A contrast-enhanced abdominal computed tomography (CT) scan revealed peritoneal carcinomatosis with massive ascites. However, his tuberculosis (TB) polymerase chai...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
A 44-year old woman with Child –Pugh A cirrhosis presented with large-volume ascites. Laboratory indices showed an international normalized ratio of 1.7, a bilirubin level of 90 umol/L, white cell count of 8.4 × 109/L, and an albumin level of 29 g/dL. Ascitic fluid analysis showed a white cell count of 35 cells/mm3, culture a nd cytology were negative, and the serum albumin-ascites gradient was 9 g/dL. Cross-sectional imaging showed no hepatocellular carcinoma or pathologic lymphadenopathy. A computed tomography–positron-emission tomography scan (Figure A) showed intense uptake of a thicken...
Source: Clinical Gastroenterology and Hepatology - Category: Gastroenterology Authors: Tags: Image of the Month Source Type: research
Viral hepatitis is a major global health problem. In 2013, an estimated 1.45 million people died from viral hepatitis.1 This is the seventh leading cause of death worldwide, ranked higher than any of the major infectious agents: human immunodeficiency virus (HIV), tuberculosis and malaria. Of these hepatitis-related deaths, most of them occur in low-income and middle-income countries (LMICs), and about half are attributable to hepatitis B virus (HBV) infection, causing cirrhosis and hepatocellular carcinoma (HCC).
Source: Journal of Hepatology - Category: Gastroenterology Authors: Tags: Research Article Source Type: research
Publication date: July 2016 Source:Medical Journal Armed Forces India, Volume 72, Issue 3 Author(s): Sandeep Satsangi, Yogesh K. Chawla Viral hepatitis is a cause for major health care burden in India and is now equated as a threat comparable to the “big three” communicable diseases – HIV/AIDS, malaria and tuberculosis. Hepatitis A virus and Hepatitis E virus are predominantly enterically transmitted pathogens and are responsible to cause both sporadic infections and epidemics of acute viral hepatitis. Hepatitis B virus and Hepatitis C virus are predominantly spread via parenteral route and are notorious...
Source: Medical Journal Armed Forces India - Category: Journals (General) Source Type: research
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