Glucose tolerance and insulin sensitivity define adipocyte transcriptional programs in human obesity

Publication date: Available online 19 September 2018Source: Molecular MetabolismAuthor(s): R. Gerlini, L. Berti, J. Darr, M. Lassi, S. Brandmaier, L. Fritsche, F. Scheid, A. Böhm, A. Königsrainer, H. Grallert, H.U. Häring, M. Hrabě de Angelis, H. Staiger, R. TeperinoAbstractObjectivesAlthough debated, metabolic health characterizes 10–25% of obese individuals and reduces risk of developing life-threatening co-morbidities. Adipose tissue is a recognized endocrine organ important for the maintenance of whole-body metabolic health. Adipocyte transcriptional signatures of healthy and unhealthy obesity are largely unknown.MethodsHere, we used a small cohort of highly characterized obese individuals discordant for metabolic health, characterized their adipocytes transcriptional signatures, and cross-referenced them to mouse phenotypic and human GWAs databases.Results and conclusionsOur study showed that glucose intolerance and insulin resistance co-operate to remodel adipocyte transcriptome. We also identified the Nuclear Export Mediator Factor (NEMF) and the Ectoderm-Neural Cortex 1 (ENC1) as novel potential targets in the management of metabolic health in human obesity.Graphical abstract
Source: Molecular Metabolism - Category: Endocrinology Source Type: research