More Than 100 Elementary School Students Stung by Wasps in British Columbia

KAMLOOPS, British Columbia - Chaos at Dufferin Elementary School today as 135 students were stung by wasps during the annual Terry Fox Run. The incident occurred just before lunch on the hillside behind the school, says Principal Colleen Topolovec. The school called in some medical personnel to help out. Thankfully, she says none of the students appeared to suffer a life-threatening reaction. Read more at   Editor's Take: Although this occured in Canada, something like this could easily happen in any of our communities. And with parents having trouble getting (or affording) Epi-pens, EMS and other first responders may need to carry extra.     Bystander Epinephrine in Community Anaphylaxis Critical Updates in Assessment &Management of Anaphylaxis Treat Anaphylactic Incidents Before it’s Too Late
Source: JEMS Patient Care - Category: Emergency Medicine Authors: Tags: International News Patient Care Source Type: news

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AbstractIntroductionDespite the numerous studies investigating drug-induced anaphylaxis (DIA), understanding and quantitative data analysis in developing countries remain limited. The aim of our study is to describe and quantify DIA using the National Pharmacovigilance Database of Vietnam (NPDV).MethodsSpontaneous reporting of adverse drug reactions (ADRs) recorded between 2010 and 2016 were retrospectively analysed to identify DIA reports. The trend and characteristics of DIA cases were described. Multivariate disproportionality analysis was used for signal generation.ResultsOverall, 4873 DIA cases (13.2% of total ADRs) w...
Source: Drug Safety - Category: Drugs & Pharmacology Source Type: research
In this study, we investigated the effects of NKA on IgE-activated bone marrow (BM)MCs and in the murine model of passive cutaneous anaphylaxis (PCA). The addition of NKA to IgE-loaded BMMCS did not affect MC degranulation, but reduced IL-4, IL-6 and IL-13 transcription.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Neuro-Cutaneous Biology and Inflammation Source Type: research
Kounis syndrome (allergic myocardial infarction) is the rare occurrence of systemic anaphylaxis with spontaneous electrocardiographic changes in response to an exogenous agent. Often the syndrome is caused by a drug reaction involving drugs such as non-steroidal anti-inflammatory drugs, antibiotics, or opioids. There are a few reported cases in the literature regarding diclofenac-induced Kounis syndrome, and little is known about the management of this clinical entity.
Source: The Journal of Emergency Medicine - Category: Emergency Medicine Authors: Tags: Clinical Communications: Adult Source Type: research
Among blood components for transfusion, plasma for direct therapeutic use is one which has the most diverse presentations as it can either be a labile (fresh) component or a drug when industrially manufactured after pooling of thousands of individual plasma collections. Therapeutic plasma can come in an unmanipulated form or be subjected to chemicals, then may or may not be followed by physical interventions. The question then arises as to whether fresh plasma retains all the moieties having therapeutic virtue and whether the manipulations (aimed at eradicating or at least eliminating infectious agents) favor adverse react...
Source: Transfusion and Apheresis Science - Category: Hematology Authors: Source Type: research
Conclusions: In asthma and allergy, multimorbidity and polypharmacy are major concerns. Disease severity, drug use, and costs increased with multimorbid conditions. To reduce the burden, allergy management should be better integrated and more comprehensive.Int Arch Allergy Immunol
Source: International Archives of Allergy and Immunology - Category: Allergy & Immunology Source Type: research
AbstractSide effects due to allergic reactions to vaccine antigen or to additives such as chicken protein or gelatin have been known for some time. Recent findings regarding reactions mediated via the carbohydrate epitope galactose-alpha-1,3-galactose (alpha-gal), a  constituent of animal gelatin, broaden the spectrum of gelatin-related allergies. This case series presents four patients who developed anaphylactic reactions following rabies vaccination using the vaccine Rabipur®. After appropriate allergy testing by skin prick testing and the determination of specific IgE to allergens in the vaccine, triggering by ...
Source: Allergo Journal International - Category: Allergy & Immunology Source Type: research
In this study, the gut microbiota of 30 LC patients and 30 healthy controls were examined via next-generation sequencing of 16S rRNA and analyzed for diversity and biomarkers. We found that there was no decrease in significant microbial diversity (alpha diversity) in LC patients compared to controls (P observed = 0.1422), while the composition (beta diversity) differed significantly between patients and controls (phylum [stress = 0.153], class [stress = 0.16], order [stress = 0.146], family [stress = 0.153]). Controls had a higher abundance of the bacterial phylum Actinobacteria and genus Bifidobacterium, while patients wi...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
Hereditary Angioedema (HAE) is a rare congenital disorder arising from decreased or dysfunctional complement C1 inhibitor (C1-INH)1 which manifests as painful, unpredictable, episodic swelling for which patients often present to the emergency department (ED). Edema of the face and oropharynx may be associated with life-threatening airway compromise, while abdominal swelling may be painful and debilitating. The latter may be associated with unnecessary surgeries or procedures2-4; while airway and facial swelling is often mistaken for allergic or anaphylactic angioedema3.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Letters Source Type: research
In conclusions, our data confirmed that there is a high number of sensitized patients to Can f 5, which have a high degree of allergic sensitization. These results should be taken into account by allergists managing dog allergic patients. In fact, clinical consequences of this sensitization regard respiratory allergy (burden of rhinitis/asthma), systemic reactions (anaphylaxis during sexual intercourse from cross-reaction with human prostatic antigen), allergen immunotherapy-AIT (likely ineffective in patients with exclusive sensitization), and preventive measures (possibility to own a female dog and a likely reduction of ...
Source: European Annals of Allergy and Clinical Immunology - Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research
Preoperative anemia affects 30 –40% of patients undergoing major surgery and is an independent risk factor for perioperative blood transfusion, morbidity, and mortality. Absolute or functional iron deficiency is its leading cause. Nonanemic hematinic deficiencies are also prevalent and may hamper preoperative hemoglobin optimiz ation and/or recovery from postoperative anemia. As modifiable risk factors, anemia and hematinic deficiencies should be detected and corrected prior to major surgical procedures. Postoperative anemia is even more common (up to 80–90%) due to surgery-associated blood loss, inflammation-i...
Source: Acta Haematologica - Category: Hematology Source Type: research
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