Livedoid Vasculopathy: an Updated Review

AbstractPurpose of ReviewTo highlight the most recent findings in the literature on livedoid vasculopathy while providing a basic review of the disease.Recent FindingsLipoprotein(a) and plasminogen activator inhibitor continue to develop evidence supporting their involvement in the pathogenesis of livedoid vasculopathy. Systematic review of the literature has revealed that anticoagulants are the most commonly reported treatments in case series followed by anabolic steroids, antiplatelets, and intravenous immunoglobulins. No randomized or controlled trials have been performed studying treatment efficacy.SummaryThe literature continues to support the hypothesis that livedoid vasculopathy is a disease of hypercoagulability and impaired fibrinolysis. There is no established treatment for livedoid vasculopathy, although a wide variety of treatments have been used to achieve partial or complete remission. Anticoagulants continue to be the most commonly reported treatment in the literature with rivaroxaban used most frequently.

Source: Current Dermatology Reports - September 1, 2018 Category: Dermatology Source Type: research