Validation of Medicinal Herbs for Anti-tyrosinase Potential

Publication date: Available online 24 September 2018Source: Journal of Herbal MedicineAuthor(s): Pulok K. Mukherjee, Rajarshi Biswas, Akanksha Sharma, Subhodip Banerjee, Sayan Biswas, C.K. KatiyarAbstractTyrosinase is a key regulatory multifunctional enzyme containing copper that is responsible for the biosynthesis of melanin that determines the color of the skin. Accumulation of excessive melanin causes various dermatological disorders including melasma and age spots. Also, tyrosinase is responsible for enzymatic browning reactions in damaged fruits and vegetables. It deteriorates the color clarity of plant-derived food product which results in loss of nutritional quality. The study of Tyrosinase inhibition is an active field of research in dermatological, biomedical, food and agricultural science and also has potential impact in the domain of insect physiology. Despite several developments on tyrosinase inhibitors, their safety concern still requires investigations due to their undesirable side-effects. Research in this context is being carried out to find potent and safe leads as tyrosinase inhibitors from medicinal plants. This review provides comprehensive overviews of various tyrosinase inhibitors obtained from medicinal plants with their mechanism of action. Several medicinal plants as tyrosinase inhibitors have been extensively studied and successfully marketed. The polyphenol and stilbenes group of phyto-molecules have been established as effective tyrosinase inhibit...
Source: Journal of Herbal Medicine - Category: Complementary Medicine Source Type: research