Let me introduce you to zein

Zein is a protein in corn (“maize” outside the U.S.) that, if held side-by-side against the gliadin protein of wheat, rye, or barley, overlaps substantially in structure (i.e., amino acid sequence). In other words, the zein protein of corn resembles the gliadin protein of other grains—not identical but with overlapping similarities in structure. This should come as no surprise, as corn and other grains share evolutionary history as grasses, not to mention ongoing exchange of genetic material over eons, given the impressive promiscuity of grasses and their ability to share and combine genetic material. (Recall how 14-chromosome ancient einkorn wheat mated with various wild grasses over the last several thousand years to yield modern 42-chromosome Triticum aestivum wheat.) Zein and gliadin are examples of prolamin proteins, a class of proteins in grasses. They are called prolamins because they are unusually rich in the amino acid, proline. Zein represents nearly half the protein in corn. (Beyond proteins, the remaining constituents of corn are largely carbohydrate-fibers, amylopectin and amylose. This explains why, when corn is reduced to a powder, as in corn meal or cornstarch, the glycemic index is the highest of any food, and why corn is used to make high-fructose corn syrup. Yes: corn is a flagrant contributor to high blood sugars, insulin resistance, inflammation, visceral fat accumulation, type 2 diabetes, and all the unhealthy phenomena associ...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: News & Updates grain-free grains Inflammation wheat belly Source Type: blogs

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Publication date: Available online 16 February 2019Source: European Journal of RadiologyAuthor(s): Lequn Zhu, Zheng Xu, Guanwu Li, Ying Wang, Xuefeng Li, Xiao Shi, Haiyang Lin, Shixin ChangAbstractBackgroundMarrow fat accumulates in diabetic conditions but remains elusive. The published works on the relationships between marrow fat phenotypes and glucose homeostasis are controversial.PurposeTo detect the association of insulin resistance with marrow adiposity in postmenopausal women with newly diagnosed type 2 diabetes (T2D) using chemical shift-encoded water–fat MRI.MethodsWe measured vertebral proton density fat fr...
Source: European Journal of Radiology - Category: Radiology Source Type: research
In this study, we aimed to evaluate the effect of a mixture of probiotics on food allergy in an ovalbumin (OVA)-induced murine model. Treatment with the probiotics attenuated OVA-induced allergic symptoms in mice. Flow cytometry analysis showed that oral administration of probiotics induced mucosal CD103+ dendritic cells (DCs), which promoted differentiation of regulatory T cells (Tregs). 16S rRNA analysis revealed that the probiotics modulated the composition of microbiota, especially by increasing the proportion of the Deferribacteres and Verrucomicrobia phyla and the Mucispirillum and Clostridium XlVa genera, which in t...
Source: Journal of Functional Foods - Category: Nutrition Source Type: research
Publication date: April 2019Source: Journal of Functional Foods, Volume 55Author(s): Anna Mas-Capdevila, Lisard Iglesias-Carres, Anna Arola-Arnal, Manuel Suarez, Begoña Muguerza, Francisca I. BravoAbstractThe aim of this study was to evaluate the effect of long-term administration of the protein hydrolysate from chicken feet Hpp11 in diet-induced hypertensive rats. Rats were fed standard or cafeteria (CAF) diets for 12 weeks, and during the final 3 weeks, CAF animals were administered vehicle, Captopril or Hpp11. Systolic blood pressure (SBP) was recorded weekly. Body weight and plasmatic lipid and glucose level...
Source: Journal of Functional Foods - Category: Nutrition Source Type: research
Publication date: April 2019Source: Journal of Functional Foods, Volume 55Author(s): Jing Li, Mei Luo, Zhen Luo, An-Yuan Guo, Xiangliang Yang, Minghua Hu, Qiong Zhang, Yanhong ZhuAbstractCyclocarya paliurus polysaccharides have been reported to prevent diabetes, but the underlying mechanisms are unclear. This current study aimed to reveal the possible underlying anti-diabetic mechanisms of CPP based on transcriptome profiling. Our experimental results demonstrated CPP could protect pancreas islets through decreasing oxidative stress and pro-inflammatory cytokines, and alleviate dyslipidemia, hepatic steatosis and liver inj...
Source: Journal of Functional Foods - Category: Nutrition Source Type: research
CONCLUSION: CXCR2, ANXA1, and CCR3 as well as olfactory receptor-related genes (proteins) may be used as biomarkers to assess zinc status in mice. PMID: 30770772 [PubMed - in process]
Source: BMC Pharmacology and Toxicology - Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research
Source: BMJ Comments - Category: General Medicine Source Type: forums
ConclusionsOur results suggest that metformin users are more likely to initiate preventive therapies and engage in other healthy behaviours. Failure to account for these behaviours may introduce healthy user bias into studies evaluating the effects of oral antihyperglycemic therapies.RésuméObjectifsLe biais lié aux utilisateurs sains selon lequel les patients ayant recours aux soins de santé sont plus susceptibles d'entreprendre des traitements préventifs et d'adopter des comportements sains liés au mode de vie est bien connu dans les études observationnelles, particuli&egra...
Source: Canadian Journal of Diabetes - Category: Endocrinology Source Type: research
This study is of potential translational significance in determining the role of gut microbiota-mediated bile acid metabolism in modulating diet-induced glucose intolerance and hepatic steatosis in the hamster.Graphical abstractIn the antibiotic-treated hamsters, hepatic CYP7B1-mediated alternative bile acid synthesis was activated. In hamsters, intestinal TβMCA accumulated and secondary bile acid levels were downregulated after gut microbiota depletion. Gut microbiota depletion-derived bile acid modulation results in intestinal FXR suppression and improvements of metabolic disorders in HFD-fed hamsters.
Source: Acta Pharmaceutica Sinica B - Category: Cancer & Oncology Source Type: research
Director chair, film slate and load horn. Here’s a proposal for you: If, by following the Wheat Belly lifestyle, a long list of conditions are reduced or reversed at no risk, almost no cost, reversing even chronic and potentially fatal conditions . . . does that mean that the notion of self-directed health might be on the horizon, i.e., putting control over health back in our own hands? I think it does. No, we will never implant our own defibrillators or take out our own gallbladders. But so many chronic health conditions afflicting modern humans recede that I believe that it is entirely reasonable to start talking a...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Wheat Belly Lifestyle arthritis autoimmune diabetes eating disorder gluten grains Inflammation joint Weight Loss Source Type: blogs
There's a universe of living organisms in your digestive tract, and the little critters can do a ton for you. Up to 100 trillion cells live in your gut microbiome, forming a world that scientists are still working to understand. 100 trillion cells -- that's enough microbes to make it the highest density natural bacterial ecosystem that we know of. Way more than your compost bin. If all is going well, these organisms live in perfect homeostasis with you, their host. From regulating your immune system to keeping the lining of your gut strong, these organisms can be a part of how you take control of your own biology. Just d...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
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