Directed Evolution of Adeno-Associated Virus Vectors in Human Cardiomyocytes for Cardiac Gene Therapy
Adeno-associated virus (AAV) vectors have become one of the most widely used systems for gene delivery. These vectors have been tested in a diverse range of pre-clinical models, ranging from liver disease to heart failure, with highly promising results. In fact, there were over 100 abstracts presented at the American Society of Gene and Cell Therapy (ASGCT) 21st Annual Meeting in Chicago in 2018 that described the use of AAV vectors in pre-clinical or clinical studies. A quick review of selected categories related to gene delivery revealed that AAV comprised nearly half of the abstracts describing the use of viral or non-viral vectors (Figure 1A).
Source: Heart, Lung and Circulation - Category: Cardiology Authors: Cindy Y. Kok, Ian Alexander, Leszek Lisowski, Eddy Kizana Tags: Editorial Source Type: research
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