Silent Aortic Stenosis Outcomes Good With Close Surveillance

(MedPage Today) -- Midterm survival rates high with medical management in registry
Source: MedPage Today Cardiovascular - Category: Cardiology Source Type: news

Related Links:

We report herein the case of a 4-year-old boy presenting with clinically isolated supravalvular aortic stenosis (SVAS). No chromosomal imbalance was detected by array CGH. The karyotype showed a balanced paracentric chromosome 7 inversion. Breakpoint characterization using paired-end whole-genome sequencing (WGS) revealed anELNgene disruption in intron 1, accounting for the phenotype. Family study showed that the inversion was inherited, with incomplete penetrance. To our knowledge, this is the first case of a disruption of theELN gene characterized by WGS. It contributes to refine the genotype-phenotype correlation inELN ...
Source: Molecular Syndromology - Category: Molecular Biology Source Type: research
Authors: Mäkikallio T, Jalava MP, Husso A, Virtanen M, Laakso T, Ahvenvaara T, Tauriainen T, Maaranen P, Kinnunen EM, Dahlbacka S, Jaakkola J, Airaksinen J, Anttila V, Savontaus M, Laine M, Juvonen T, Valtola A, Raivio P, Eskola M, Niemelä M, Biancari F Abstract AIM: We investigated the outcomes of transcatheter (TAVR) and surgical aortic valve replacement (SAVR) in Finland during the last decade. METHODS: The nationwide FinnValve registry included data from 6463 patients who underwent TAVR or SAVR with a bioprosthesis for aortic stenosis from 2008 to 2017. RESULTS: The annual number of treated pa...
Source: Annals of Medicine - Category: Internal Medicine Tags: Ann Med Source Type: research
CONCLUSION: Arterial hypertension and elevated diastolic blood pressure are associated with a risk for AS requiring surgery in subjects below 60 years of age. Strict blood pressure control in this group is strongly advocated to avoid other cardiovascular diseases correlated to hypertension. If hypertension and elevated diastolic blood pressure are risk factors for developing AS requiring surgery need further investigations. Notably, elevated fasting glucose levels were related to AS requiring surgery in older adults without concomitant CAD. PMID: 31109205 [PubMed - in process]
Source: Scandinavian Cardiovascular Journal - Category: Cardiology Tags: Scand Cardiovasc J Source Type: research
Transcatheter aortic valve replacement (TAVR) is currently the standard of care for inoperable or high-risk patients with symptomatic severe aortic stenosis, and a treatment option for patients deemed at intermediate operatory risk [1 –3]. Because of the notably comorbidities burden and the relatively high rate of periprocedural complication, up to 25% of patients undergoing TAVR refer to unplanned hospital readmissions [4,5]. Of note, hospital readmissions have been associated with a worse prognosis.
Source: International Journal of Cardiology - Category: Cardiology Authors: Source Type: research
ConclusionsRelative to transfemoral TAVR, patients undergoing transapical TAVR are at increased risk for new-onset bundle branch block, peri-procedural myocardial infarction, rehospitalization, TAV-in-TAV deployment, and all-cause mortality at 1  year. Interventional cardiologists and cardiothoracic surgeons alike should take these findings into consideration when choosing which approach is most suitable for patients undergoing TAVR for severe aortic stenosis.
Source: Cardiology and Therapy - Category: Cardiology Source Type: research
Authors: Hourai R, Ozawa H, Sohmiya K, Hirose Y, Katsumata T, Daimon M, Ishizaka N Abstract The prevalence and extent of immunoglobulin G4 (IgG4)-positive cell infiltration were investigated in 282 surgical samples of aortic wall and aortic valve. Tissue infiltration of IgG4-positive cells was observed in 24 (17.3%) of 139 aortic valve samples and 46 (32%) of 143 aortic wall samples, and the condition of IgG4-positive cell infiltration> 30/hpf together with IgG4/CD138 ratio> 40% was observed in 2 (1.4%) of aortic valve samples and 14 (9.8%) of aortic wall samples. Among 275 patients, preoperative serum IgG4 l...
Source: International Heart Journal - Category: Cardiology Tags: Int Heart J Source Type: research
Authors: Ren X, Li F, Wang C, Hou Z, Gao Y, Yin W, Lu B Abstract Bicuspid aortic valve (BAV) is the most common congenital heart disease. Different distribution of valve dysfunction was found in patients with BAV in different age and sex groups, but related difference was not well established. The aim of our study is to investigate age- and sex-related clinical characteristics differences in patients with BAV.Six hundred twenty patients with BAV who had moderate or severe aortic valve dysfunction were included in the study. Basic clinical data and image data were recorded. Patients were classified into four differe...
Source: International Heart Journal - Category: Cardiology Tags: Int Heart J Source Type: research
Symptomatic severe aortic stenosis (AS) is the most common indication for valvular interventions.1 AS is a degenerative and progressive disease that characteristically remains asymptomatic for decades but once symptoms occur, survival is severely compromised.
Source: Radcliffe Cardiology - Category: Cardiology Authors: Source Type: research
AbstractThe reliability of fractional flow reserve (FFR) in aortic stenosis (AS) has been questioned because of the uncertain response to vasodilators. A retrospective multicenter cohort of 114 AS patients who underwent coronary physiology assessment was compared with 154 controls before and after propensity matching adjustment. The difference between resting distal coronary vs aortic pressure ratio (Pd/Pa) and FFR ( ΔPd/Pa-FFR) was tested against the severity of AS. ΔPd/Pa-FFR was not influenced by the severity of AS in terms of aortic valve area (r = − 0.02,p = 0.83) a...
Source: Journal of Cardiovascular Translational Research - Category: Cardiology Source Type: research
We report herein the case of a 4-year-old boy presenting with clinically isolated supravalvular aortic stenosis (SVAS). No chromosomal imbalance was detected by array CGH. The karyotype showed a balanced paracentric chromosome 7 inversion. Breakpoint characterization using paired-end whole-genome sequencing (WGS) revealed anELNgene disruption in intron 1, accounting for the phenotype. Family study showed that the inversion was inherited, with incomplete penetrance. To our knowledge, this is the first case of a disruption of theELN gene characterized by WGS. It contributes to refine the genotype-phenotype correlation inELN ...
Source: Molecular Syndromology - Category: Molecular Biology Source Type: research
More News: Aortic Stenosis | Cardiology | Cardiovascular | Heart