Benefit of adjuvant radiotherapy following narrow-margin hepatectomy in patients with intrahepatic cholangiocarcinoma that adhere to major vessels

Source: Cancer Management and Research - Category: Cancer & Oncology Tags: Cancer Management and Research Source Type: research

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Conclusion.This study demonstrates that merestinib has a tolerable safety profile and potential anticancer activity and warrants further clinical investigation.Implications for Practice.Merestinib treatment in patients with advanced cancer demonstrated an acceptable safety profile and potential antitumor activity, supporting its future development in specific disease populations as a monotherapy and/or in combination with other therapies.
Source: The Oncologist - Category: Cancer & Oncology Authors: Tags: Head and Neck Cancers, Melanoma and Cutaneous Malignancies, Gastrointestinal Cancer New Drug Development and Clinical Pharmacology Source Type: research
Circular RNAs (circRNAs) play a vital role in cancers. Accumulated evidences showed that the physiological condition of cells can be reflected by the circRNAs in the exosomes they secrete, and these exosomal circRNAs can be captured by the receptor cells, thereby inducing a series of cellular responses. We performed qRT-PCR to detect the expression level of circ-0000284 in cholangiocarcinoma cell lines, tissues and plasma exosomes. Then the direct interaction between circ-0000284 and miR-637 was investigated through dual-luciferase reporter assay, RIP assay and FISH assay. Subsequently, EdU, migration, invasion assay, flow...
Source: Clinical Science - Category: Biomedical Science Authors: Tags: PublishAheadOfPrint Source Type: research
ConclusionWe provide evidence that LRRK2 was an independent prognostic factor for ICC in humans by participating in the proliferation and metastasis of ICC cells.
Source: Digestive Diseases and Sciences - Category: Gastroenterology Source Type: research
Conditions:   Gastrointestinal Cancer;   Colorectal Cancer;   Pancreatic Adenocarcinoma;   Gastric Cancer;   Esophageal Cancer;   Cholangiocarcinoma;   Hepatocellular Carcinoma;   Neuroendocrine Tumors;   GIST, Malignant Interventions:   Behavioral: Serious Illness Conversation Guide (SICG);   Behavioral: Quality of Life (QOL) survey Sponsor:   Stanford University Not yet recruiting
Source: - Category: Research Source Type: clinical trials
Early recurrence after hepatectomy for intrahepatic cholangiocarcinoma (ICC) has a great effect on the long-term survival outcomes of patients. We conducted this study to identify risk factors for early recurrence and clarify whether early recurrence is related to ICC patients’ long-term survival outcomes. 322 ICC patients who underwent partial hepatectomy at Liver Cancer Institute of Zhongshan Hospital between January 2005 and December 2011 were included in this retrospectively study. Early recurrence was defined as ICC recurrence within two years after hepatectomy. We identified a total of 168 patients with early r...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Abstract Chronic infections with the food-borne liver flukes, Opisthorchis viverrini or Clonorchis sinensis, associate with cholangiocarcinoma, bile duct cancer, which generally has a poor prognosis. We have produced a rapid and simple immunochromatographic test (ICT) kit for the diagnosis of opisthorchiasis and clonorchiasis by the detection of IgG antibodies in human infection sera. Sera from volunteers with proven opisthorchiasis and several other parasitic diseases and from healthy controls were evaluated for the presence of liver fluke infection-specific antibodies using a preparation of excretory-secretory a...
Source: The American Journal of Tropical Medicine and Hygiene - Category: Tropical Medicine Authors: Tags: Am J Trop Med Hyg Source Type: research
Conditions:   Cholangiocarcinoma;   Bile Duct Cancer Intervention:   Drug: Trifluridine/Tipiracil Sponsors:   Sunnybrook Health Sciences Centre;   Taiho Pharma Canada, Inc. Not yet recruiting
Source: - Category: Research Source Type: clinical trials
More News: Bile Duct Cancer | Cancer | Cancer & Oncology | Cholangiocarcinoma