EGFR-TKI-sensitive mutations in lung carcinomas: are they related to clinical features and CT findings?

Source: Cancer Management and Research - Category: Cancer & Oncology Tags: Cancer Management and Research Source Type: research

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Authors: Ahmed SR, Petersen E, Patel R, Migden MR Abstract INTRODUCTION: In September of 2018, the United States Federal Drug Administration (FDA) approved cemiplimab-rwlc (Libtayo) for advanced cutaneous squamous cell carcinoma (CSCC). Cemiplimab is an intravenous human monoclonal antibody directed against programmed cell death-1 receptor (PD-1). Cemiplimab blocks T-cell inactivation and enhances the immune system's anti-tumor response. Areas Covered: We review CSCC and the studies leading to cemiplimab's approval, including common side effects and safety issues experienced during the clinical trials. Expert Opini...
Source: Expert Review of Clinical Pharmacology - Category: Drugs & Pharmacology Tags: Expert Rev Clin Pharmacol Source Type: research
Publication date: Available online 17 September 2019Source: Genes &DiseasesAuthor(s): Prasanna.K. Santhekadur, Divya.P. KumarAbstractRNA-induced silencing complex (RISC) is one of the basic eukaryotic cellular machinery which plays a pivotal role in post-transcriptional gene regulation. Discovery of miRNAs and their role in gene regulation have changed the course of modern biology. The method of gene silencing using small interfering RNAs and miRNAs has become major tool in molecular biology and genetic engineering. Hepatocellular carcinoma (HCC) is a very common malignancy of liver in developing countries and due to v...
Source: Genes and Diseases - Category: Genetics & Stem Cells Source Type: research
Publication date: Available online 17 September 2019Source: Urology Case ReportsAuthor(s): Lim HC, Khong TL, Ong TA, Roslani AC, Ang CWAbstractBladder perforation secondary to transurethral resection of bladder tumour (TURBT) increases the risk of tumour seeding and eventual extravesicle metastasis. Here we presented a case where a patient with localised bladder tumour was initially managed with repeated TURBT for tumour recurrence. Subsequently he was found to have extravesicle pelvic metastasis. This was likely secondary to microperforation of bladder and tumour seeding. Microscopic bladder perforation is difficult to di...
Source: Urology Case Reports - Category: Urology & Nephrology Source Type: research
Publication date: Available online 17 September 2019Source: Journal of Advanced ResearchAuthor(s): Peio Errarte, Gorka Larrinaga, José I. LópezAbstractCancer-associated fibroblasts (CAF) are a cellular compartment of the tumor microenvironment with critical roles in tumor development. Fibroblast activation protein-α (FAP) is one of the proteins expressed by CAF and its immunohistochemical detection in routine practice is associated with tumor aggressiveness and shorter patient survival. For these reasons, FAP seems a good prognostic marker in many malignant neoplasms, including renal cell carcinoma (RCC...
Source: Journal of Advanced Research - Category: Research Source Type: research
Conditions:   Hepatocellular Carcinoma;   Hepatoblastoma Interventions:   Genetic: TEGAR T cells;   Drug: Cytoxan;   Drug: Fludarabine Sponsors:   Baylor College of Medicine;   Texas Children's Hospital;   The Methodist Hospital System Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
This 61-year-old woman presented with new primary triple negative breast cancer (TNBC) in the lateral breast 10 years after completing radiation for ductal carcinoma in situ (DCIS) in the same breast.1 Despite neoadjuvant chemotherapy and mastectomy with only residual DCIS and negative nodes, patient developed a TNBC re-recurrence only 9 months later. She was treated with chemotherapy, and there remains positive residual localized disease by positron emission tomography (PET). At this point we recommend the following.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Gray Zone Source Type: research
Circulating tumor DNA (ctDNA) as a cancer biomarker may assist in detection, risk stratification, treatment assessment, and surveillance. There are limited data on the rates of detectability and ctDNA kinetics in the post-operative (post-op) setting for patients with Human Papilloma Virus (HPV)-associated oropharyngeal squamous cell carcinoma (HPV-OPSCC). We aimed to investigate ctDNA detectability rates by post-op risk category and association with prognosis in this population.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Source Type: research
Source: Cancer Management and Research - Category: Cancer & Oncology Tags: Cancer Management and Research Source Type: research
Publication date: Available online 17 September 2019Source: European UrologyAuthor(s): Eugene Shkolyar, Xiao Jia, Timothy C. Chang, Dharati Trivedi, Kathleen E. Mach, Max Q.-H. Meng, Lei Xing, Joseph C. LiaoAbstractAdequate tumor detection is critical in complete transurethral resection of bladder tumor (TURBT) to reduce cancer recurrence, but up to 20% of bladder tumors are missed by standard white light cystoscopy. Deep learning augmented cystoscopy may improve tumor localization, intraoperative navigation, and surgical resection of bladder cancer. We aimed to develop a deep learning algorithm for augmented cystoscopic d...
Source: European Urology - Category: Urology & Nephrology Source Type: research
AbstractObjectivesThe aim of this study is to evaluate the surgical results of clinical N1 disease and to clarify the high-risk clinical N1 subgroup.MethodsBetween 1990 and 2012, 137 patients who were clinically diagnosed as having N1 disease were enrolled. Their medical records were reviewed to assess clinical characteristics, radiologic findings, pathologic results, postoperative outcomes, recurrence patterns, and survival. Logistic regression analysis was used to identify independent predictive factors for pathologic N2 upstaging. To determine which factors were significantly associated with survival, a multivariate ana...
Source: General Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
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