Epigenetic markers in basal cell carcinoma: universal themes in oncogenesis and tumor stratification? - a short report

ConclusionsOur data reveal an EZH2-associated epigenetic marker profile that correlates with histologic signs of BCC aggressiveness. Our findings may have diagnostic and therapeutic implications, and indicate that epigenetic markers may be shared even with relatively less aggressive tumor types, thereby suggesting universal themes.
Source: Cellular Oncology - Category: Cancer & Oncology Source Type: research

Related Links:

Vismodegib demonstrated 60% response rates in the ERIVANCE trial. Basal cell carcinoma (BCC) has various histopathologies. Their impact on response is unclear.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Authors: Source Type: research
ConclusionsDefining the role of RT in the management of BCC and cSCC has been hindered by a lack of high-quality evidence. This document synthesizes available evidence to define practice guidelines for the most common clinical situations. We encourage practitioners to enroll patients in prospective trials and to approach care in a multidisciplinary fashion whenever possible.
Source: Practical Radiation Oncology - Category: Cancer & Oncology Source Type: research
CONCLUSION: Alternative treatment options for periocular BCC are available; however, the use is only indicated when microscopically controlled excision with subsequent oculoplastic reconstruction is not possible. According to the national guidelines a prior presentation to a suitable tumor board is practically compulsory. PMID: 31811367 [PubMed - as supplied by publisher]
Source: Der Ophthalmologe - Category: Opthalmology Authors: Tags: Ophthalmologe Source Type: research
Contributors : Rehan M Villani ; Edwige Roy ; Valentine Murigneux ; Seen L Sim ; Christiane Malapitan ; Jack Gailbraith ; Stuti Kupadia ; Lynn Fink ; Kiarash KhosrotehraniSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBasal Cell Carcinoma (BCC) is known to rely heavily on interactions with its niche but little is understood regarding how the various cell types interact. In order to determine specifically how the Cancer associated fibroblasts (CAFs) in the BCC niche impact tumor development we have undertaken cell type specific RNA sequencing and have identified signalling mechanisms ...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Publication date: Available online 27 November 2019Source: European Journal of Surgical OncologyAuthor(s): A.J.P. Clover, S.P. Salwa, M.G. Bourke, J. McKiernan, P.F. Forde, S.T. O'Sullivan, E.J. Kelly, D.M. SodenAbstractBasal cell carcinoma (BCC) are the commonest cutaneous malignancy and incidence continues to increase. There is a need to expand the therapeutic toolbox to increase options for patients that are unsuitable for or unwilling to undergo the current therapies.Electrochemotherapy (ECT) is a technique where cells are temporarily permeabilized after exposure to a brief pulsed electrical field and combined with low...
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
Now Available at Dermatology Specialists of Mississippi in Biloxi Biloxi, MS – Dermatology Specialists of Mississippi is now offering Superficial Radiation Therapy (SRT) as a treatment option for patients with non-melanoma skin cancer. This advanced technology is offered in less than 1% of dermatology clinics and has a 95%+ cure rate for non-melanoma skin cancer. There are four million new cases of basal cell carcinoma and squamous cell carcinoma diagnosed in the United States each year... DermRads
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Radiation Oncology Source Type: forums
In a previous study, our group demonstrated that cultured autologous fibroblast-seeded artificial dermis was superior to artificial dermis for covering defects after surgical excision of basal cell carcinoma (BCC) in terms of scar quality. However, utilizing cultured cells for clinical purposes requires Food and Drug Administration-approved facilities and techniques and a lengthy culture period. The purpose of this retrospective study was to compare the effects of tissue-engineered dermis containing stromal vascular fraction (SVF) cells with artificial dermis on scar quality after surgical excision of BCC on the nose.
Source: Journal of Plastic, Reconstructive and Aesthetic Surgery - Category: Cosmetic Surgery Authors: Source Type: research
No abstract available
Source: Dermatologic Surgery - Category: Dermatology Tags: Letters and Communications Source Type: research
Opinion statementAdvanced basal cell carcinoma (BCC) represents a small proportion of BCCs that are not amenable to standard therapies due to lack of efficacy, high recurrence risk, and excessive morbidity. Implication of the Sonic hedgehog (Shh) pathway in the development of BCC has led to the development of systemic Shh pathway inhibitors, providing patients with advanced BCCs new treatment options and improved survival. There are currently two Food and Drug Administration (FDA) –approved Shh inhibitors, vismodegib and sonidegib, for advanced basal cell carcinomas. Vismodegib has approval for locally advanced BCCs ...
Source: Current Treatment Options in Oncology - Category: Cancer & Oncology Source Type: research
Authors: Bueno Filho R, Fantini BC, Santos CAD, Melo RVG, Rosan I, Chahud F, Souza CDS Abstract Background: Residual tumors increase the likelihood of recurrence of basal cell carcinoma (BCC).Objective: We determined the attributes and risk factors for positive surgical margins (+SM) of excised BCC in a university hospital.Methods: In this cross-sectional retrospective study, we reviewed the histologic reports of BCC removed via conventional surgical excision (CSE) by specialists from different fields.Results: Among excised BCCs (n = 864), there was a predominance of nodular BCC (82.64%) in the facial...
Source: Journal of Dermatological Treatment - Category: Dermatology Tags: J Dermatolog Treat Source Type: research
More News: Basal Cell Carcinoma | Cancer & Oncology | Carcinoma | Skin Cancer | Study