Identification of an enhancer region within the TP63 / LEPREL1 locus containing genetic variants associated with bladder cancer risk

ConclusionsTaken together, our data show that bladder cancer risk-associated variants on chromosome 3q28 are located in an active enhancer region. Further characterization of the allele-specific activity of the identified enhancer and its target genes may lead to the identification of novel signaling pathways involved in bladder carcinogenesis.
Source: Cellular Oncology - Category: Cancer & Oncology Source Type: research