Mesenchymal marker and LGR5 expression levels in circulating tumor cells correlate with colorectal cancer prognosis
AbstractPurposeThe presence of circulating tumor cells (CTCs) has been found to correlate with colorectal cancer (CRC) prognosis, whereas epithelial-mesenchymal transition (EMT) in CTCs has been found to be associated with CRC metastasis. LGR5 is a known target of Wnt signaling and plays an important role in CRC development. The aim of this study was to assess the clinical relevance of EMT and LGR5 expression in CTCs from CRC patients.MethodsSixty-six CRC patients were included in this study. The detection and expression of EMT phenotypes in CTCs from these patients were assessed using CanPatrol ™ CTC enrichment and mRNA in situ hybridization (ISH), respectively. LGR5 expression in the CTCs was assessed using mRNA ISH.ResultsCTCs were detected in 86.4% (57/66) of the CRC patients included. Both the numbers of total CTCs and of CTCs displaying a mesenchymal phenotype (M+ CTCs) were found to significantly correlate with advanced disease stages and the occurrence of metastasis (p
CONCLUSION: The combination of niclosamide and temozolomide effectively decreased the stemness and invasive properties of GBM TSs, suggesting that this regimen may be therapeutically effective in treating patients with GBM. PMID: 32712753 [PubMed - indexed for MEDLINE]
CONCLUSIONS: Probiotics can inhibit the development of alcohol-induced CRC by protecting intestinal permeability. PMID: 33015778 [PubMed - in process]
Authors: Wang DK, Chong RF, Song BL, Fan KF, Liu YF Abstract Since this article has been suspected of research misconduct and the corresponding authors did not respond to our request to prove originality of data and figures, "Circular RNA circ-SMAD7 is downregulated in colorectal cancer and suppresses tumor metastasis by regulating epithelial mesenchymal transition, by D.-K. Wang, R.-F. Chong, B.-L. Song, K.-F. Fan, Y.-F. Liu, published in Eur Rev Med Pharmacol Sci 2020; 24 (4): 1736-1742-DOI: 10.26355/eurrev_202002_20350-PMID: 32141541" has been withdrawn. The Publisher apologizes for any inconvenience t...
CONCLUSIONS: Our study demonstrated that IH and gut microbiota of patients with OSAS activated HIF-1α expression and STAT3 pathway in IMCE cells, with no influence on β-catenin pathway, which suggested that IH, STAT3 pathway, chronic inflammation, and intestinal microbiota dysbiosis may be involved in CRC carcinogenesis correlated with OSAS These findings must be interpreted cautiously and further research is necessary to clarify the causative steps in CRC development. PMID: 33029691 [PubMed - as supplied by publisher]
ConclusionsOur study demonstrated that IH and gut microbiota of patients with OSAS activated HIF-1 α expression and STAT3 pathway in IMCE cells, with no influence on β-catenin pathway, which suggested that IH, STAT3 pathway, chronic inflammation, and intestinal microbiota dysbiosis may be involved in CRC carcinogenesis correlated with OSAS These findings must be interpreted cautiously and furth er research is necessary to clarify the causative steps in CRC development.
ConclusionstPNPs improved stability and efficacy of CFZin vitro, and these results potentiate effective cancer treatment using CFZ/tPNPs in future vivo studies.
Conclusions: This study illustrated the role of COMP in EMT and suggested that COMP/TAGLN may be a potential tumor therapeutic target. Chrysin exhibits obvious antitumor effects. This work provides a preliminary antitumor therapy to target COMP or its interaction protein to inhibit EMT.
Conclusion: Our results suggest that the CSRP2/p130Cas/Rac1 axis can inhibit CRC aggressiveness and metastasis through the Hippo, ERK, and PAK signaling pathways. Therefore, CSRP2 may be a potential therapeutic target for CRC.
CONCLUSION: The newly synthesized complexes have the potential to be further investigated as metallodrugs. PMID: 32998677 [PubMed - as supplied by publisher]