Fusobacterium nucleatum promotes M2 polarization of macrophages in the microenvironment of colorectal tumours via a TLR4-dependent mechanism

In conclusion, we show thatFn infection increased M2 polarization of macrophages in vitro and in vivo. Furthermore,Fn infection enhanced colorectal tumour growth in a TLR4-dependent manner involving activation of the IL-6/p-STAT3/c-MYC signalling pathway. For the first time, our results indicate an immunosuppressive effect ofFn by promoting M2 polarization of macrophages through a TLR4-dependent mechanism, which may serve as a promising target for immunotherapy ofFn-related CRC.
Source: Cancer Immunology, Immunotherapy - Category: Cancer & Oncology Source Type: research