Remission of aggressive autoimmune disease (dermatomyositis) with removal of infective jaw pathology and ozone therapy: review and case report

ConclusionDental focus of occult infection may be a prime cause/trigger of autoimmune disorders and inflammatory disorders, requiring surgical intervention to remove. Ozone therapy, little known in conventional medicine, has been shown in the literature and in this case to be a powerful and safe immune modulator and anti-infective agent. This case has significant relevance across the entire spectrum of both medical and dental practice. It also emphasizes the need for individualized assessment and treatment rather than symptomatic pharmacological approaches treating a “disease” rather than the patient. Subclinical dental infection and ozone therapy are reviewed.
Source: Autoimmunity Highlights - Category: Allergy & Immunology Source Type: research

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Conclusions The results of the present study may be indicative for an impaired oxidative metabolism in work-related trapezius myalgia. However, additional research is necessary to confirm this hypothesis.
Source: American Journal of Physical Medicine and Rehabilitation - Category: Rehabilitation Tags: Original Research Articles Source Type: research
This study aims to assess whether ultrasound-guided injection of platelet-rich plasma can safely and effectively treat symptoms associated with acetabular hip labral tears. Design Institutional review board approval was gained for a prospective study of eight patients (N = 8), who have previously failed conservative management, to receive ultrasound-guided injection of platelet-rich plasma at the site of hip labrum tear. We assessed pain reduction and functional ability at baseline and then 2, 6, and 8 wks after injection, using the visual analog scale and Harris Hip Score, respectively. Results Statistically signifi...
Source: American Journal of Physical Medicine and Rehabilitation - Category: Rehabilitation Tags: Original Research Articles Source Type: research
In this study, we retrospectively analyzed data of a group FUO/IUO patients that suspected of PMR, aiming to analyze the imaging features of PMR in FDG PET/CT and evaluate the clinical value of FDG PET/CT in differential diagnosis of PMR. Materials and Methods: From January 2014 to June 2018, among the patients who underwent PET/CT examination because of FUO/IUO, 26 patients were suspected of PMR due to shoulder joint pain and stiffness, increased serum inflammatory factors and age over 50 years old. Clinical and imaging data of these 26 patients were retrospectively analyzed. Final diagnoses were made by board-certified r...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Outcomes/Infectious Disease/Pulmonary Posters Source Type: research
Conclusions Normal muscle contains a considerable number of macrophages and T-lymphocytes. Muscle biopsy is likely to detect inflammatory changes in patients with myalgia or hyperCKemia only if pathologic EMG findings are present.
Source: Neurology Neuroimmunology and Neuroinflammation - Category: Neurology Authors: Tags: Autoimmune diseases, Muscle disease, EMG Article Source Type: research
AbstractPurpose of ReviewWe synthesised the literature on productivity losses and costs in the less-common systemic autoimmune rheumatic diseases: Sjogren ’s syndrome (SjS), systemic sclerosis (SSc), poly/dermatomyositis (PM/DM), and systemic vasculitides (SV).Recent FindingsOf 29 studies located, 12 were published 2012 onwards (SSc  = 6, SjS = 2, PM/DM = 2, SV = 2). In these, 25% of PM/DM, and 21–26% of SV, were work disabled, 22% of SSc stopped work within 3 years of diagnosis, and annual costs of absenteeism in SSc averaged $12,024 2017 USD. Very few studies repor...
Source: Current Rheumatology Reports - Category: Rheumatology Source Type: research
We report here 4 cases (3 adults and 1 child) of TC treated with ivSTS. TC was secondary to CREST syndrome, dermatomyositis (1 adult and 1 child) and systemic erythematous lupus and involved multiple sites in all cases. In all 4 patients, TC was responsible for joint pain, reduced mobility, inflammatory flares and skin fistulations. One patient experienced difficulty sitting due to the pain induced by calcified lesions on the buttock; another patient had major disability, moved only with wheelchair and was under opioid treatment for pain. For all patients, treatment with several medications be...
Source: Joint Bone Spine - Category: Orthopaedics Source Type: research
Conclusion: Here, we present a rare case of DM caused by non-hepatitis-associated advanced HCC with colonic perforation. The cause of colonic perforation is still unclear. This case demonstrates the need to carefully monitor abdominal pain in DM patients as symptoms can be masked by steroid therapy.Case Rep Oncol 2016;9:547 –553
Source: Case Reports in Oncology - Category: Cancer & Oncology Source Type: research
kó K Abstract Myositis, which means inflammation of the muscles, is a general term used for inflammatory myopathies. Myositis is a rare idiopathic autoimmune disease. It is believed that environmental factors such as virus, bacteria, parasites, direct injuries, drugs side effect can trigger the immune system of genetically susceptible individuals to act against muscle tissues. There are several types of myositis with the same systemic symptoms such as muscle weakness, fatigue, muscle pain and inflammation. These include dermatomyositis, juvenile dermatomyositis, inclusion-body myositis, polymyositis, orbita...
Source: Orvosi Hetilap - Category: Journals (General) Authors: Tags: Orv Hetil Source Type: research
Conclusions Our case report highlights the importance of a thorough search for underlying malignancy in patients with dermatomyositis even if dermatomyositis has a mild appearance or a discrete skin manifestation.
Source: Journal of Medical Case Reports - Category: Journals (General) Source Type: research
Idiopathic inflammatory myopathies (IIMs) are characterised by inflammatory involvement of skeletal muscles causing weakness and pain, with possible associated systemic manifestations including frequent interstitial lung disease (ILD), and significant morbidity and mortality. Accumulating evidence suggests an important contribution of autoimmune responses to the pathogenesis of these diseases. Autoantibodies are present in at least half of patients with IIMs [1]. Some of these autoantibodies are frequently detected in patients with other connective diseases associated with myositis (especially systematic sclerosis) and are...
Source: European Respiratory Review - Category: Respiratory Medicine Authors: Tags: Interstitial and orphan lung disease Letter Source Type: research
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